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Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides
Polysaccharides are a class of carbohydrates that play pivotal roles in living systems such as being chemical messengers in many vital biological pathways. However, the complexity and heterogeneity of these natural structures have posed daunting challenges on their production, characterization, eval...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435236/ https://www.ncbi.nlm.nih.gov/pubmed/32832369 http://dx.doi.org/10.1002/advs.202001264 |
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author | Wang, Hanxuan Liu, Zhichao An, Chuanjing Li, Haoting Hu, Fanlei Dong, Suwei |
author_facet | Wang, Hanxuan Liu, Zhichao An, Chuanjing Li, Haoting Hu, Fanlei Dong, Suwei |
author_sort | Wang, Hanxuan |
collection | PubMed |
description | Polysaccharides are a class of carbohydrates that play pivotal roles in living systems such as being chemical messengers in many vital biological pathways. However, the complexity and heterogeneity of these natural structures have posed daunting challenges on their production, characterization, evaluation, and applications. While there have been various types of synthetic skeletons that could mimic some biological aspects of polysaccharides, a safer and more easily accessed system is still desired to avoid the unnatural components and difficulties in modifying the structures. In this work, conveniently accessible self‐assembling glycopeptide conjugates are developed, where the natural O‐glycosidic linkages and phosphoryl modifications assist the self‐assembly and concurrently reduce the risk of toxicity. The generated nanoparticles in aqueous solution offer a multivalent display of structurally controllable carbohydrates as mimics of polysaccharides, among which a mannosylated version exhibits immunostimulatory effects in both cellular assays and vaccination of mice. The obtained results demonstrate the potential of this glycopeptide conjugate‐derived platform in exploiting the intriguing properties of carbohydrates in a more structurally maneuverable fashion. |
format | Online Article Text |
id | pubmed-7435236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74352362020-08-20 Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides Wang, Hanxuan Liu, Zhichao An, Chuanjing Li, Haoting Hu, Fanlei Dong, Suwei Adv Sci (Weinh) Full Papers Polysaccharides are a class of carbohydrates that play pivotal roles in living systems such as being chemical messengers in many vital biological pathways. However, the complexity and heterogeneity of these natural structures have posed daunting challenges on their production, characterization, evaluation, and applications. While there have been various types of synthetic skeletons that could mimic some biological aspects of polysaccharides, a safer and more easily accessed system is still desired to avoid the unnatural components and difficulties in modifying the structures. In this work, conveniently accessible self‐assembling glycopeptide conjugates are developed, where the natural O‐glycosidic linkages and phosphoryl modifications assist the self‐assembly and concurrently reduce the risk of toxicity. The generated nanoparticles in aqueous solution offer a multivalent display of structurally controllable carbohydrates as mimics of polysaccharides, among which a mannosylated version exhibits immunostimulatory effects in both cellular assays and vaccination of mice. The obtained results demonstrate the potential of this glycopeptide conjugate‐derived platform in exploiting the intriguing properties of carbohydrates in a more structurally maneuverable fashion. John Wiley and Sons Inc. 2020-07-02 /pmc/articles/PMC7435236/ /pubmed/32832369 http://dx.doi.org/10.1002/advs.202001264 Text en © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Wang, Hanxuan Liu, Zhichao An, Chuanjing Li, Haoting Hu, Fanlei Dong, Suwei Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides |
title | Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides |
title_full | Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides |
title_fullStr | Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides |
title_full_unstemmed | Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides |
title_short | Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides |
title_sort | self‐assembling glycopeptide conjugate as a versatile platform for mimicking complex polysaccharides |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435236/ https://www.ncbi.nlm.nih.gov/pubmed/32832369 http://dx.doi.org/10.1002/advs.202001264 |
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