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Tissue-targeted R-spondin mimetics for liver regeneration

R-spondin (RSPO) proteins amplify Wnt signaling and stimulate regeneration in a variety of tissues. To repair tissue in a tissue-specific manner, tissue-targeted RSPO mimetic molecules are desired. Here, we mutated RSPO (RSPO2 F105R/F109A) to eliminate LGR binding while preserving ZNRF3/RNF43 bindin...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhengjian, Broderick, Caroline, Nishimoto, Marni, Yamaguchi, Teppei, Lee, Sung-Jin, Zhang, Haili, Chen, Hui, Patel, Mehaben, Ye, Jay, Ponce, Alberto, Brady, Jennifer, Baribault, Hélène, Li, Yang, Yeh, Wen-Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435267/ https://www.ncbi.nlm.nih.gov/pubmed/32811902 http://dx.doi.org/10.1038/s41598-020-70912-3

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