Cell Growth Inhibition of Saponin XII from Dipsacus japonicus Miq. on Acute Myeloid Leukemia Cells

In previous studies, we isolated the known compound saponin XII from the roots of Dipsacus japonicus Miq. Here, we show that this compound reduced the number of acute myeloid leukemia OCI-AML3 cells as evaluated by a hemocytometer. Flow cytometry analyses demonstrated that the reported activity was...

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Detalles Bibliográficos
Autores principales: Cham, Ba Thi, Linh, Nguyen Thi Thuy, Thao, Do Thi, Anh, Nguyen Thi Hoang, Tam, Nguyen Thanh, Anh, Bui Kim, Muscari, Isabella, Adorisio, Sabrina, Sung, Tran Van, Thuy, Trinh Thi, Delfino, Domenico V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435407/
https://www.ncbi.nlm.nih.gov/pubmed/32707961
http://dx.doi.org/10.3390/molecules25153325
Descripción
Sumario:In previous studies, we isolated the known compound saponin XII from the roots of Dipsacus japonicus Miq. Here, we show that this compound reduced the number of acute myeloid leukemia OCI-AML3 cells as evaluated by a hemocytometer. Flow cytometry analyses demonstrated that the reported activity was associated with a significant increase of apoptosis and of cells in the G(0)/G(1) phase of the cell cycle, with a decrease of cells in the S and G(2)/M phases. Thus, the inhibition of cell growth in OCI-AML3 cells was due to antiproliferative and pro-apoptotic effects. Interestingly, the bioactivity of saponin XII exerted its effect at a concentration as low as 1 µg/mL.

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