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Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine
We review developments in fluorine chemistry contributing to the more precise use of fluorinated pyrimidines (FPs) to treat cancer. 5-Fluorouracil (5-FU) is the most widely used FP and is used to treat > 2 million cancer patients each year. We review methods for 5-FU synthesis, including the inco...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435603/ https://www.ncbi.nlm.nih.gov/pubmed/32751071 http://dx.doi.org/10.3390/molecules25153438 |