PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation

Melanocytes, replenished throughout life by melanocyte stem cells (MSCs), play a critical role in pigmentation and melanoma. Here, we reveal a function for the metastasis-associated phosphatase of regenerating liver 3 (PRL3) in MSC regeneration. We show that PRL3 binds to the RNA helicase DDX21, the...

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Detalles Bibliográficos
Autores principales: Johansson, Jeanette A., Marie, Kerrie L., Lu, Yuting, Brombin, Alessandro, Santoriello, Cristina, Zeng, Zhiqiang, Zich, Judith, Gautier, Philippe, von Kriegsheim, Alex, Brunsdon, Hannah, Wheeler, Ann P., Dreger, Marcel, Houston, Douglas R., Dooley, Christopher M., Sims, Andrew H., Busch-Nentwich, Elisabeth M., Zon, Leonard I., Illingworth, Robert S., Patton, E. Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435699/
https://www.ncbi.nlm.nih.gov/pubmed/32652076
http://dx.doi.org/10.1016/j.devcel.2020.06.013

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