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Point-of-Care Diagnostics in Coagulation Management
This review provides a comprehensive and up-to-date overview of point-of-care (POC) devices most commonly used for coagulation analyses in the acute settings. Fast and reliable assessment of hemostasis is essential for the management of trauma and other bleeding patients. Routine coagulation assays...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435714/ https://www.ncbi.nlm.nih.gov/pubmed/32751629 http://dx.doi.org/10.3390/s20154254 |
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author | Sahli, Sebastian D. Rössler, Julian Tscholl, David W. Studt, Jan-Dirk Spahn, Donat R. Kaserer, Alexander |
author_facet | Sahli, Sebastian D. Rössler, Julian Tscholl, David W. Studt, Jan-Dirk Spahn, Donat R. Kaserer, Alexander |
author_sort | Sahli, Sebastian D. |
collection | PubMed |
description | This review provides a comprehensive and up-to-date overview of point-of-care (POC) devices most commonly used for coagulation analyses in the acute settings. Fast and reliable assessment of hemostasis is essential for the management of trauma and other bleeding patients. Routine coagulation assays are not designed to visualize the process of clot formation, and their results are obtained only after 30–90 m due to the requirements of sample preparation and the analytical process. POC devices such as viscoelastic coagulation tests, platelet function tests, blood gas analysis and other coagulometers provide new options for the assessment of hemostasis, and are important tools for an individualized, goal-directed, and factor-based substitution therapy. We give a detailed overview of the related tests, their characteristics and clinical implications. This review emphasizes the evident advantages of the speed and predictive power of POC clot measurement in the context of a goal-directed and algorithm-based therapy to improve the patient’s outcome. Interpretation of viscoelastic tests is facilitated by a new visualization technology. |
format | Online Article Text |
id | pubmed-7435714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74357142020-08-28 Point-of-Care Diagnostics in Coagulation Management Sahli, Sebastian D. Rössler, Julian Tscholl, David W. Studt, Jan-Dirk Spahn, Donat R. Kaserer, Alexander Sensors (Basel) Review This review provides a comprehensive and up-to-date overview of point-of-care (POC) devices most commonly used for coagulation analyses in the acute settings. Fast and reliable assessment of hemostasis is essential for the management of trauma and other bleeding patients. Routine coagulation assays are not designed to visualize the process of clot formation, and their results are obtained only after 30–90 m due to the requirements of sample preparation and the analytical process. POC devices such as viscoelastic coagulation tests, platelet function tests, blood gas analysis and other coagulometers provide new options for the assessment of hemostasis, and are important tools for an individualized, goal-directed, and factor-based substitution therapy. We give a detailed overview of the related tests, their characteristics and clinical implications. This review emphasizes the evident advantages of the speed and predictive power of POC clot measurement in the context of a goal-directed and algorithm-based therapy to improve the patient’s outcome. Interpretation of viscoelastic tests is facilitated by a new visualization technology. MDPI 2020-07-30 /pmc/articles/PMC7435714/ /pubmed/32751629 http://dx.doi.org/10.3390/s20154254 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sahli, Sebastian D. Rössler, Julian Tscholl, David W. Studt, Jan-Dirk Spahn, Donat R. Kaserer, Alexander Point-of-Care Diagnostics in Coagulation Management |
title | Point-of-Care Diagnostics in Coagulation Management |
title_full | Point-of-Care Diagnostics in Coagulation Management |
title_fullStr | Point-of-Care Diagnostics in Coagulation Management |
title_full_unstemmed | Point-of-Care Diagnostics in Coagulation Management |
title_short | Point-of-Care Diagnostics in Coagulation Management |
title_sort | point-of-care diagnostics in coagulation management |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435714/ https://www.ncbi.nlm.nih.gov/pubmed/32751629 http://dx.doi.org/10.3390/s20154254 |
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