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Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties

Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infection...

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Detalles Bibliográficos
Autores principales: Maslova, Anna A., Matyugina, Elena S., Snoeck, Robert, Andrei, Graciela, Kochetkov, Sergey N., Khandazhinskaya, Anastasia L., Novikov, Mikhail S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435738/
https://www.ncbi.nlm.nih.gov/pubmed/32717979
http://dx.doi.org/10.3390/molecules25153350
Descripción
Sumario:Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infections can accelerate the acute phase of HIV infection and AIDS. Thus, the idea of designing compounds that could combine activity against HIV and co-infections would seem promising. In that regard, eleven compounds were synthesized that represent conjugates of non-nucleoside HIV reverse transcriptase inhibitors and nucleoside inhibitors of the herpes family viruses with the hope that these novel heterodimers will result in dual activity against HIV and concomitant herpes virus infections.