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Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties

Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infection...

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Autores principales: Maslova, Anna A., Matyugina, Elena S., Snoeck, Robert, Andrei, Graciela, Kochetkov, Sergey N., Khandazhinskaya, Anastasia L., Novikov, Mikhail S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435738/
https://www.ncbi.nlm.nih.gov/pubmed/32717979
http://dx.doi.org/10.3390/molecules25153350
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author Maslova, Anna A.
Matyugina, Elena S.
Snoeck, Robert
Andrei, Graciela
Kochetkov, Sergey N.
Khandazhinskaya, Anastasia L.
Novikov, Mikhail S.
author_facet Maslova, Anna A.
Matyugina, Elena S.
Snoeck, Robert
Andrei, Graciela
Kochetkov, Sergey N.
Khandazhinskaya, Anastasia L.
Novikov, Mikhail S.
author_sort Maslova, Anna A.
collection PubMed
description Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infections can accelerate the acute phase of HIV infection and AIDS. Thus, the idea of designing compounds that could combine activity against HIV and co-infections would seem promising. In that regard, eleven compounds were synthesized that represent conjugates of non-nucleoside HIV reverse transcriptase inhibitors and nucleoside inhibitors of the herpes family viruses with the hope that these novel heterodimers will result in dual activity against HIV and concomitant herpes virus infections.
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spelling pubmed-74357382020-08-25 Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties Maslova, Anna A. Matyugina, Elena S. Snoeck, Robert Andrei, Graciela Kochetkov, Sergey N. Khandazhinskaya, Anastasia L. Novikov, Mikhail S. Molecules Article Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infections can accelerate the acute phase of HIV infection and AIDS. Thus, the idea of designing compounds that could combine activity against HIV and co-infections would seem promising. In that regard, eleven compounds were synthesized that represent conjugates of non-nucleoside HIV reverse transcriptase inhibitors and nucleoside inhibitors of the herpes family viruses with the hope that these novel heterodimers will result in dual activity against HIV and concomitant herpes virus infections. MDPI 2020-07-23 /pmc/articles/PMC7435738/ /pubmed/32717979 http://dx.doi.org/10.3390/molecules25153350 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maslova, Anna A.
Matyugina, Elena S.
Snoeck, Robert
Andrei, Graciela
Kochetkov, Sergey N.
Khandazhinskaya, Anastasia L.
Novikov, Mikhail S.
Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties
title Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties
title_full Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties
title_fullStr Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties
title_full_unstemmed Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties
title_short Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties
title_sort uracil-containing heterodimers of a new type: synthesis and study of their anti-viral properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435738/
https://www.ncbi.nlm.nih.gov/pubmed/32717979
http://dx.doi.org/10.3390/molecules25153350
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