Cargando…
Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties
Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infection...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435738/ https://www.ncbi.nlm.nih.gov/pubmed/32717979 http://dx.doi.org/10.3390/molecules25153350 |
_version_ | 1783572392042299392 |
---|---|
author | Maslova, Anna A. Matyugina, Elena S. Snoeck, Robert Andrei, Graciela Kochetkov, Sergey N. Khandazhinskaya, Anastasia L. Novikov, Mikhail S. |
author_facet | Maslova, Anna A. Matyugina, Elena S. Snoeck, Robert Andrei, Graciela Kochetkov, Sergey N. Khandazhinskaya, Anastasia L. Novikov, Mikhail S. |
author_sort | Maslova, Anna A. |
collection | PubMed |
description | Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infections can accelerate the acute phase of HIV infection and AIDS. Thus, the idea of designing compounds that could combine activity against HIV and co-infections would seem promising. In that regard, eleven compounds were synthesized that represent conjugates of non-nucleoside HIV reverse transcriptase inhibitors and nucleoside inhibitors of the herpes family viruses with the hope that these novel heterodimers will result in dual activity against HIV and concomitant herpes virus infections. |
format | Online Article Text |
id | pubmed-7435738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74357382020-08-25 Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties Maslova, Anna A. Matyugina, Elena S. Snoeck, Robert Andrei, Graciela Kochetkov, Sergey N. Khandazhinskaya, Anastasia L. Novikov, Mikhail S. Molecules Article Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infections can accelerate the acute phase of HIV infection and AIDS. Thus, the idea of designing compounds that could combine activity against HIV and co-infections would seem promising. In that regard, eleven compounds were synthesized that represent conjugates of non-nucleoside HIV reverse transcriptase inhibitors and nucleoside inhibitors of the herpes family viruses with the hope that these novel heterodimers will result in dual activity against HIV and concomitant herpes virus infections. MDPI 2020-07-23 /pmc/articles/PMC7435738/ /pubmed/32717979 http://dx.doi.org/10.3390/molecules25153350 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maslova, Anna A. Matyugina, Elena S. Snoeck, Robert Andrei, Graciela Kochetkov, Sergey N. Khandazhinskaya, Anastasia L. Novikov, Mikhail S. Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties |
title | Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties |
title_full | Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties |
title_fullStr | Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties |
title_full_unstemmed | Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties |
title_short | Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties |
title_sort | uracil-containing heterodimers of a new type: synthesis and study of their anti-viral properties |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435738/ https://www.ncbi.nlm.nih.gov/pubmed/32717979 http://dx.doi.org/10.3390/molecules25153350 |
work_keys_str_mv | AT maslovaannaa uracilcontainingheterodimersofanewtypesynthesisandstudyoftheirantiviralproperties AT matyuginaelenas uracilcontainingheterodimersofanewtypesynthesisandstudyoftheirantiviralproperties AT snoeckrobert uracilcontainingheterodimersofanewtypesynthesisandstudyoftheirantiviralproperties AT andreigraciela uracilcontainingheterodimersofanewtypesynthesisandstudyoftheirantiviralproperties AT kochetkovsergeyn uracilcontainingheterodimersofanewtypesynthesisandstudyoftheirantiviralproperties AT khandazhinskayaanastasial uracilcontainingheterodimersofanewtypesynthesisandstudyoftheirantiviralproperties AT novikovmikhails uracilcontainingheterodimersofanewtypesynthesisandstudyoftheirantiviralproperties |