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Synthesis and Antimicrobial Evaluation of Some New Organic Tellurium Compounds Based on Pyrazole Derivatives

A novel series of organic tellurium compounds based on pyrazole derivatives with a general formula of ArTeBr(3) and Ar(2)TeBr(2) [Ar = 2-(3-(4-substituted phenyl) -5-(2-chlorophenyl)-1H-pyrazol-1-yl)-3,5-dinitrophenyl] were obtained by the refluxing of corresponding aryl mercuric chlorides with TeBr...

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Autores principales: Sabti, Asmaa B., Al-Fregi, Adil A., Yousif, Majeed Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435781/
https://www.ncbi.nlm.nih.gov/pubmed/32751090
http://dx.doi.org/10.3390/molecules25153439
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author Sabti, Asmaa B.
Al-Fregi, Adil A.
Yousif, Majeed Y.
author_facet Sabti, Asmaa B.
Al-Fregi, Adil A.
Yousif, Majeed Y.
author_sort Sabti, Asmaa B.
collection PubMed
description A novel series of organic tellurium compounds based on pyrazole derivatives with a general formula of ArTeBr(3) and Ar(2)TeBr(2) [Ar = 2-(3-(4-substituted phenyl) -5-(2-chlorophenyl)-1H-pyrazol-1-yl)-3,5-dinitrophenyl] were obtained by the refluxing of corresponding aryl mercuric chlorides with TeBr(4) in two different mole ratio of 1:1 and 2:1, respectively, in free-moisture dioxane solvent under an argon atmosphere. Compounds of ArTeBr(3) and Ar(2)TeBr(2) were reduced by the action of ethanolic solution of hydrazine hydrate obtained Ar(2)Te(2) and Ar(2)Te, respectively. Reaction of Ar(2)Te(2) with excess thionyl chloride or iodine gave the corresponding trihalides ArTeCl(3) and ArTeI(3), respectively while the reaction of Ar(2)Te with thionyl chloride or iodine gave the corresponding Ar(2)TeCl(3) and Ar(2)TeI(3), respectively. The structures were elucidated according to their elemental analysis of carbon, hydrogen and nitrogen (CHN) and some of the spectroscopic techniques such as infrared IR and nuclear magnetic resonance for (1)H and (13)C. The antimicrobial activity for all the synthetic compounds were assayed against both Gram-negative and Gram-positive bacteria by using the agar diffusion method. The tellurated pyrazole derivatives showed a good degree against bacteria growth. In some cases, the antimicrobial activities of the synthetic compounds were better than amoxicillin.
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spelling pubmed-74357812020-08-25 Synthesis and Antimicrobial Evaluation of Some New Organic Tellurium Compounds Based on Pyrazole Derivatives Sabti, Asmaa B. Al-Fregi, Adil A. Yousif, Majeed Y. Molecules Article A novel series of organic tellurium compounds based on pyrazole derivatives with a general formula of ArTeBr(3) and Ar(2)TeBr(2) [Ar = 2-(3-(4-substituted phenyl) -5-(2-chlorophenyl)-1H-pyrazol-1-yl)-3,5-dinitrophenyl] were obtained by the refluxing of corresponding aryl mercuric chlorides with TeBr(4) in two different mole ratio of 1:1 and 2:1, respectively, in free-moisture dioxane solvent under an argon atmosphere. Compounds of ArTeBr(3) and Ar(2)TeBr(2) were reduced by the action of ethanolic solution of hydrazine hydrate obtained Ar(2)Te(2) and Ar(2)Te, respectively. Reaction of Ar(2)Te(2) with excess thionyl chloride or iodine gave the corresponding trihalides ArTeCl(3) and ArTeI(3), respectively while the reaction of Ar(2)Te with thionyl chloride or iodine gave the corresponding Ar(2)TeCl(3) and Ar(2)TeI(3), respectively. The structures were elucidated according to their elemental analysis of carbon, hydrogen and nitrogen (CHN) and some of the spectroscopic techniques such as infrared IR and nuclear magnetic resonance for (1)H and (13)C. The antimicrobial activity for all the synthetic compounds were assayed against both Gram-negative and Gram-positive bacteria by using the agar diffusion method. The tellurated pyrazole derivatives showed a good degree against bacteria growth. In some cases, the antimicrobial activities of the synthetic compounds were better than amoxicillin. MDPI 2020-07-29 /pmc/articles/PMC7435781/ /pubmed/32751090 http://dx.doi.org/10.3390/molecules25153439 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sabti, Asmaa B.
Al-Fregi, Adil A.
Yousif, Majeed Y.
Synthesis and Antimicrobial Evaluation of Some New Organic Tellurium Compounds Based on Pyrazole Derivatives
title Synthesis and Antimicrobial Evaluation of Some New Organic Tellurium Compounds Based on Pyrazole Derivatives
title_full Synthesis and Antimicrobial Evaluation of Some New Organic Tellurium Compounds Based on Pyrazole Derivatives
title_fullStr Synthesis and Antimicrobial Evaluation of Some New Organic Tellurium Compounds Based on Pyrazole Derivatives
title_full_unstemmed Synthesis and Antimicrobial Evaluation of Some New Organic Tellurium Compounds Based on Pyrazole Derivatives
title_short Synthesis and Antimicrobial Evaluation of Some New Organic Tellurium Compounds Based on Pyrazole Derivatives
title_sort synthesis and antimicrobial evaluation of some new organic tellurium compounds based on pyrazole derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435781/
https://www.ncbi.nlm.nih.gov/pubmed/32751090
http://dx.doi.org/10.3390/molecules25153439
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