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Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve

One new dibenzocycloheptene, validinol (1), and one butanolide firstly isolated from the natural source, validinolide (2), together with 17 known compounds were isolated from the stem of Cinnamomum validinerve. Among the isolates, lincomolide A (3), secosubamolide (7), and cinnamtannin B1 (19) exhib...

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Autores principales: Yang, Chi-Lung, Wu, Ho-Cheng, Hwang, Tsong-Long, Lin, Chu-Hung, Cheng, Yin-Hua, Wang, Chia-Chi, Kan, Hung-Lin, Kuo, Yueh-Hsiung, Chen, Ih-Sheng, Chang, Hsun-Shuo, Lin, Ying-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435785/
https://www.ncbi.nlm.nih.gov/pubmed/32722482
http://dx.doi.org/10.3390/molecules25153382
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author Yang, Chi-Lung
Wu, Ho-Cheng
Hwang, Tsong-Long
Lin, Chu-Hung
Cheng, Yin-Hua
Wang, Chia-Chi
Kan, Hung-Lin
Kuo, Yueh-Hsiung
Chen, Ih-Sheng
Chang, Hsun-Shuo
Lin, Ying-Chi
author_facet Yang, Chi-Lung
Wu, Ho-Cheng
Hwang, Tsong-Long
Lin, Chu-Hung
Cheng, Yin-Hua
Wang, Chia-Chi
Kan, Hung-Lin
Kuo, Yueh-Hsiung
Chen, Ih-Sheng
Chang, Hsun-Shuo
Lin, Ying-Chi
author_sort Yang, Chi-Lung
collection PubMed
description One new dibenzocycloheptene, validinol (1), and one butanolide firstly isolated from the natural source, validinolide (2), together with 17 known compounds were isolated from the stem of Cinnamomum validinerve. Among the isolates, lincomolide A (3), secosubamolide (7), and cinnamtannin B1 (19) exhibited potent inhibition on both superoxide anion generation (IC(50) values of 2.98 ± 0.3 µM, 4.37 ± 0.38 µM, and 2.20 ± 0.3 µM, respectively) and elastase release (IC(50) values of 3.96 ± 0.31 µM, 3.04 ± 0.23 µM, and 4.64 ± 0.71 µM, respectively) by human neutrophils. In addition, isophilippinolide A (6), secosubamolide (7), and cinnamtannin B1 (19) showed bacteriostatic effects against Propionibacterium acnes in in vitro study, with minimal inhibitory concentration (MIC) values at 16 μg/mL, 16 μg/mL, and 500 μg/mL, respectively. Further investigations using the in vivo ear P. acnes infection model showed that the intraperitoneal administration of the major component cinnamtannin B1 (19) reduced immune cell infiltration and pro-inflammatory cytokines TNF-α and IL-6 at the infection sites. The results demonstrated the potential of cinnamtannin B1 (19) for acne therapy. In summary, these results demonstrated the anti-inflammatory potentials of Formosan C. validinerve during bacterial infections.
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spelling pubmed-74357852020-08-25 Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve Yang, Chi-Lung Wu, Ho-Cheng Hwang, Tsong-Long Lin, Chu-Hung Cheng, Yin-Hua Wang, Chia-Chi Kan, Hung-Lin Kuo, Yueh-Hsiung Chen, Ih-Sheng Chang, Hsun-Shuo Lin, Ying-Chi Molecules Article One new dibenzocycloheptene, validinol (1), and one butanolide firstly isolated from the natural source, validinolide (2), together with 17 known compounds were isolated from the stem of Cinnamomum validinerve. Among the isolates, lincomolide A (3), secosubamolide (7), and cinnamtannin B1 (19) exhibited potent inhibition on both superoxide anion generation (IC(50) values of 2.98 ± 0.3 µM, 4.37 ± 0.38 µM, and 2.20 ± 0.3 µM, respectively) and elastase release (IC(50) values of 3.96 ± 0.31 µM, 3.04 ± 0.23 µM, and 4.64 ± 0.71 µM, respectively) by human neutrophils. In addition, isophilippinolide A (6), secosubamolide (7), and cinnamtannin B1 (19) showed bacteriostatic effects against Propionibacterium acnes in in vitro study, with minimal inhibitory concentration (MIC) values at 16 μg/mL, 16 μg/mL, and 500 μg/mL, respectively. Further investigations using the in vivo ear P. acnes infection model showed that the intraperitoneal administration of the major component cinnamtannin B1 (19) reduced immune cell infiltration and pro-inflammatory cytokines TNF-α and IL-6 at the infection sites. The results demonstrated the potential of cinnamtannin B1 (19) for acne therapy. In summary, these results demonstrated the anti-inflammatory potentials of Formosan C. validinerve during bacterial infections. MDPI 2020-07-25 /pmc/articles/PMC7435785/ /pubmed/32722482 http://dx.doi.org/10.3390/molecules25153382 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Chi-Lung
Wu, Ho-Cheng
Hwang, Tsong-Long
Lin, Chu-Hung
Cheng, Yin-Hua
Wang, Chia-Chi
Kan, Hung-Lin
Kuo, Yueh-Hsiung
Chen, Ih-Sheng
Chang, Hsun-Shuo
Lin, Ying-Chi
Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve
title Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve
title_full Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve
title_fullStr Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve
title_full_unstemmed Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve
title_short Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve
title_sort anti-inflammatory and antibacterial activity constituents from the stem of cinnamomum validinerve
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435785/
https://www.ncbi.nlm.nih.gov/pubmed/32722482
http://dx.doi.org/10.3390/molecules25153382
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