Cargando…
3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency
Additive manufacturing technologies have been widely used in the medical field. More specifically, fused filament fabrication (FFF) 3D-printing technology has been thoroughly investigated to produce drug delivery systems. Recently, few researchers have explored the possibility of directly 3D printin...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435804/ https://www.ncbi.nlm.nih.gov/pubmed/32751210 http://dx.doi.org/10.3390/ma13153364 |
_version_ | 1783572407542349824 |
---|---|
author | Shaqour, Bahaa Reigada, Inés Górecka, Żaneta Choińska, Emilia Verleije, Bart Beyers, Koen Święszkowski, Wojciech Fallarero, Adyary Cos, Paul |
author_facet | Shaqour, Bahaa Reigada, Inés Górecka, Żaneta Choińska, Emilia Verleije, Bart Beyers, Koen Święszkowski, Wojciech Fallarero, Adyary Cos, Paul |
author_sort | Shaqour, Bahaa |
collection | PubMed |
description | Additive manufacturing technologies have been widely used in the medical field. More specifically, fused filament fabrication (FFF) 3D-printing technology has been thoroughly investigated to produce drug delivery systems. Recently, few researchers have explored the possibility of directly 3D printing such systems without the need for producing a filament which is usually the feedstock material for the printer. This was possible via direct feeding of a mixture consisting of the carrier polymer and the required drug. However, as this direct feeding approach shows limited homogenizing abilities, it is vital to investigate the effect of the pre-mixing step on the quality of the 3D printed products. Our study investigates the two commonly used mixing approaches—solvent casting and powder mixing. For this purpose, polycaprolactone (PCL) was used as the main polymer under investigation and gentamicin sulfate (GS) was selected as a reference. The produced systems’ efficacy was investigated for bacterial and biofilm prevention. Our data show that the solvent casting approach offers improved drug distribution within the polymeric matrix, as was observed from micro-computed topography and scanning electron microscopy visualization. Moreover, this approach shows a higher drug release rate and thus improved antibacterial efficacy. However, there were no differences among the tested approaches in terms of thermal and mechanical properties. |
format | Online Article Text |
id | pubmed-7435804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74358042020-08-25 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency Shaqour, Bahaa Reigada, Inés Górecka, Żaneta Choińska, Emilia Verleije, Bart Beyers, Koen Święszkowski, Wojciech Fallarero, Adyary Cos, Paul Materials (Basel) Article Additive manufacturing technologies have been widely used in the medical field. More specifically, fused filament fabrication (FFF) 3D-printing technology has been thoroughly investigated to produce drug delivery systems. Recently, few researchers have explored the possibility of directly 3D printing such systems without the need for producing a filament which is usually the feedstock material for the printer. This was possible via direct feeding of a mixture consisting of the carrier polymer and the required drug. However, as this direct feeding approach shows limited homogenizing abilities, it is vital to investigate the effect of the pre-mixing step on the quality of the 3D printed products. Our study investigates the two commonly used mixing approaches—solvent casting and powder mixing. For this purpose, polycaprolactone (PCL) was used as the main polymer under investigation and gentamicin sulfate (GS) was selected as a reference. The produced systems’ efficacy was investigated for bacterial and biofilm prevention. Our data show that the solvent casting approach offers improved drug distribution within the polymeric matrix, as was observed from micro-computed topography and scanning electron microscopy visualization. Moreover, this approach shows a higher drug release rate and thus improved antibacterial efficacy. However, there were no differences among the tested approaches in terms of thermal and mechanical properties. MDPI 2020-07-29 /pmc/articles/PMC7435804/ /pubmed/32751210 http://dx.doi.org/10.3390/ma13153364 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shaqour, Bahaa Reigada, Inés Górecka, Żaneta Choińska, Emilia Verleije, Bart Beyers, Koen Święszkowski, Wojciech Fallarero, Adyary Cos, Paul 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency |
title | 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency |
title_full | 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency |
title_fullStr | 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency |
title_full_unstemmed | 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency |
title_short | 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency |
title_sort | 3d-printed drug delivery systems: the effects of drug incorporation methods on their release and antibacterial efficiency |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435804/ https://www.ncbi.nlm.nih.gov/pubmed/32751210 http://dx.doi.org/10.3390/ma13153364 |
work_keys_str_mv | AT shaqourbahaa 3dprinteddrugdeliverysystemstheeffectsofdrugincorporationmethodsontheirreleaseandantibacterialefficiency AT reigadaines 3dprinteddrugdeliverysystemstheeffectsofdrugincorporationmethodsontheirreleaseandantibacterialefficiency AT goreckazaneta 3dprinteddrugdeliverysystemstheeffectsofdrugincorporationmethodsontheirreleaseandantibacterialefficiency AT choinskaemilia 3dprinteddrugdeliverysystemstheeffectsofdrugincorporationmethodsontheirreleaseandantibacterialefficiency AT verleijebart 3dprinteddrugdeliverysystemstheeffectsofdrugincorporationmethodsontheirreleaseandantibacterialefficiency AT beyerskoen 3dprinteddrugdeliverysystemstheeffectsofdrugincorporationmethodsontheirreleaseandantibacterialefficiency AT swieszkowskiwojciech 3dprinteddrugdeliverysystemstheeffectsofdrugincorporationmethodsontheirreleaseandantibacterialefficiency AT fallareroadyary 3dprinteddrugdeliverysystemstheeffectsofdrugincorporationmethodsontheirreleaseandantibacterialefficiency AT cospaul 3dprinteddrugdeliverysystemstheeffectsofdrugincorporationmethodsontheirreleaseandantibacterialefficiency |