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3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency

Additive manufacturing technologies have been widely used in the medical field. More specifically, fused filament fabrication (FFF) 3D-printing technology has been thoroughly investigated to produce drug delivery systems. Recently, few researchers have explored the possibility of directly 3D printin...

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Autores principales: Shaqour, Bahaa, Reigada, Inés, Górecka, Żaneta, Choińska, Emilia, Verleije, Bart, Beyers, Koen, Święszkowski, Wojciech, Fallarero, Adyary, Cos, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435804/
https://www.ncbi.nlm.nih.gov/pubmed/32751210
http://dx.doi.org/10.3390/ma13153364
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author Shaqour, Bahaa
Reigada, Inés
Górecka, Żaneta
Choińska, Emilia
Verleije, Bart
Beyers, Koen
Święszkowski, Wojciech
Fallarero, Adyary
Cos, Paul
author_facet Shaqour, Bahaa
Reigada, Inés
Górecka, Żaneta
Choińska, Emilia
Verleije, Bart
Beyers, Koen
Święszkowski, Wojciech
Fallarero, Adyary
Cos, Paul
author_sort Shaqour, Bahaa
collection PubMed
description Additive manufacturing technologies have been widely used in the medical field. More specifically, fused filament fabrication (FFF) 3D-printing technology has been thoroughly investigated to produce drug delivery systems. Recently, few researchers have explored the possibility of directly 3D printing such systems without the need for producing a filament which is usually the feedstock material for the printer. This was possible via direct feeding of a mixture consisting of the carrier polymer and the required drug. However, as this direct feeding approach shows limited homogenizing abilities, it is vital to investigate the effect of the pre-mixing step on the quality of the 3D printed products. Our study investigates the two commonly used mixing approaches—solvent casting and powder mixing. For this purpose, polycaprolactone (PCL) was used as the main polymer under investigation and gentamicin sulfate (GS) was selected as a reference. The produced systems’ efficacy was investigated for bacterial and biofilm prevention. Our data show that the solvent casting approach offers improved drug distribution within the polymeric matrix, as was observed from micro-computed topography and scanning electron microscopy visualization. Moreover, this approach shows a higher drug release rate and thus improved antibacterial efficacy. However, there were no differences among the tested approaches in terms of thermal and mechanical properties.
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spelling pubmed-74358042020-08-25 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency Shaqour, Bahaa Reigada, Inés Górecka, Żaneta Choińska, Emilia Verleije, Bart Beyers, Koen Święszkowski, Wojciech Fallarero, Adyary Cos, Paul Materials (Basel) Article Additive manufacturing technologies have been widely used in the medical field. More specifically, fused filament fabrication (FFF) 3D-printing technology has been thoroughly investigated to produce drug delivery systems. Recently, few researchers have explored the possibility of directly 3D printing such systems without the need for producing a filament which is usually the feedstock material for the printer. This was possible via direct feeding of a mixture consisting of the carrier polymer and the required drug. However, as this direct feeding approach shows limited homogenizing abilities, it is vital to investigate the effect of the pre-mixing step on the quality of the 3D printed products. Our study investigates the two commonly used mixing approaches—solvent casting and powder mixing. For this purpose, polycaprolactone (PCL) was used as the main polymer under investigation and gentamicin sulfate (GS) was selected as a reference. The produced systems’ efficacy was investigated for bacterial and biofilm prevention. Our data show that the solvent casting approach offers improved drug distribution within the polymeric matrix, as was observed from micro-computed topography and scanning electron microscopy visualization. Moreover, this approach shows a higher drug release rate and thus improved antibacterial efficacy. However, there were no differences among the tested approaches in terms of thermal and mechanical properties. MDPI 2020-07-29 /pmc/articles/PMC7435804/ /pubmed/32751210 http://dx.doi.org/10.3390/ma13153364 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shaqour, Bahaa
Reigada, Inés
Górecka, Żaneta
Choińska, Emilia
Verleije, Bart
Beyers, Koen
Święszkowski, Wojciech
Fallarero, Adyary
Cos, Paul
3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency
title 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency
title_full 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency
title_fullStr 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency
title_full_unstemmed 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency
title_short 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency
title_sort 3d-printed drug delivery systems: the effects of drug incorporation methods on their release and antibacterial efficiency
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435804/
https://www.ncbi.nlm.nih.gov/pubmed/32751210
http://dx.doi.org/10.3390/ma13153364
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