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Stable Formulations of Peptide-Based Nanogels
Recently, nanogels have been identified as innovative formulations for enlarging the application of hydrogels (HGs) in the area of drug delivery or in diagnostic imaging. Nanogels are HGs-based aggregates with sizes in the range of nanometers and formulated in order to obtain injectable preparations...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435922/ https://www.ncbi.nlm.nih.gov/pubmed/32751321 http://dx.doi.org/10.3390/molecules25153455 |
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author | Rosa, Elisabetta Diaferia, Carlo Gallo, Enrico Morelli, Giancarlo Accardo, Antonella |
author_facet | Rosa, Elisabetta Diaferia, Carlo Gallo, Enrico Morelli, Giancarlo Accardo, Antonella |
author_sort | Rosa, Elisabetta |
collection | PubMed |
description | Recently, nanogels have been identified as innovative formulations for enlarging the application of hydrogels (HGs) in the area of drug delivery or in diagnostic imaging. Nanogels are HGs-based aggregates with sizes in the range of nanometers and formulated in order to obtain injectable preparations. Regardless of the advantages offered by peptides in a hydrogel preparation, until now, only a few examples of peptide-based nanogels (PBNs) have been developed. Here, we describe the preparation of stable PBNs based on Fmoc-Phe-Phe-OH using three different methods, namely water/oil emulsion (W/O), top-down, and nanogelling in water. The effect of the hydrophilic–lipophilic balance (HLB) in the formulation was also evaluated in terms of size and stability. The resulting nanogels were found to encapsulate the anticancer drug doxorubicin, chosen as the model drug, with a drug loading comparable with those of the liposomes. |
format | Online Article Text |
id | pubmed-7435922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74359222020-08-24 Stable Formulations of Peptide-Based Nanogels Rosa, Elisabetta Diaferia, Carlo Gallo, Enrico Morelli, Giancarlo Accardo, Antonella Molecules Article Recently, nanogels have been identified as innovative formulations for enlarging the application of hydrogels (HGs) in the area of drug delivery or in diagnostic imaging. Nanogels are HGs-based aggregates with sizes in the range of nanometers and formulated in order to obtain injectable preparations. Regardless of the advantages offered by peptides in a hydrogel preparation, until now, only a few examples of peptide-based nanogels (PBNs) have been developed. Here, we describe the preparation of stable PBNs based on Fmoc-Phe-Phe-OH using three different methods, namely water/oil emulsion (W/O), top-down, and nanogelling in water. The effect of the hydrophilic–lipophilic balance (HLB) in the formulation was also evaluated in terms of size and stability. The resulting nanogels were found to encapsulate the anticancer drug doxorubicin, chosen as the model drug, with a drug loading comparable with those of the liposomes. MDPI 2020-07-29 /pmc/articles/PMC7435922/ /pubmed/32751321 http://dx.doi.org/10.3390/molecules25153455 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rosa, Elisabetta Diaferia, Carlo Gallo, Enrico Morelli, Giancarlo Accardo, Antonella Stable Formulations of Peptide-Based Nanogels |
title | Stable Formulations of Peptide-Based Nanogels |
title_full | Stable Formulations of Peptide-Based Nanogels |
title_fullStr | Stable Formulations of Peptide-Based Nanogels |
title_full_unstemmed | Stable Formulations of Peptide-Based Nanogels |
title_short | Stable Formulations of Peptide-Based Nanogels |
title_sort | stable formulations of peptide-based nanogels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435922/ https://www.ncbi.nlm.nih.gov/pubmed/32751321 http://dx.doi.org/10.3390/molecules25153455 |
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