Cargando…

Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study

Although transcranial photoacoustic imaging (TCPAI) has been used in small animal brain imaging, in animals with thicker skull bones or in humans both light illumination and ultrasound propagation paths are affected. Hence, the PA image is largely degraded and in some cases completely distorted. Thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Manwar, Rayyan, Kratkiewicz, Karl, Avanaki, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435985/
https://www.ncbi.nlm.nih.gov/pubmed/32731449
http://dx.doi.org/10.3390/s20154189
_version_ 1783572449440301056
author Manwar, Rayyan
Kratkiewicz, Karl
Avanaki, Kamran
author_facet Manwar, Rayyan
Kratkiewicz, Karl
Avanaki, Kamran
author_sort Manwar, Rayyan
collection PubMed
description Although transcranial photoacoustic imaging (TCPAI) has been used in small animal brain imaging, in animals with thicker skull bones or in humans both light illumination and ultrasound propagation paths are affected. Hence, the PA image is largely degraded and in some cases completely distorted. This study aims to investigate and determine the maximum thickness of the skull through which photoacoustic imaging is feasible in terms of retaining the imaging target structure without incorporating any post processing. We identify the effect of the skull on both the illumination path and acoustic propagation path separately and combined. In the experimental phase, the distorting effect of ex vivo sheep skull bones with thicknesses in the range of 0.7~1.3 mm are explored. We believe that the findings in this study facilitate the clinical translation of TCPAI.
format Online
Article
Text
id pubmed-7435985
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74359852020-08-24 Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study Manwar, Rayyan Kratkiewicz, Karl Avanaki, Kamran Sensors (Basel) Article Although transcranial photoacoustic imaging (TCPAI) has been used in small animal brain imaging, in animals with thicker skull bones or in humans both light illumination and ultrasound propagation paths are affected. Hence, the PA image is largely degraded and in some cases completely distorted. This study aims to investigate and determine the maximum thickness of the skull through which photoacoustic imaging is feasible in terms of retaining the imaging target structure without incorporating any post processing. We identify the effect of the skull on both the illumination path and acoustic propagation path separately and combined. In the experimental phase, the distorting effect of ex vivo sheep skull bones with thicknesses in the range of 0.7~1.3 mm are explored. We believe that the findings in this study facilitate the clinical translation of TCPAI. MDPI 2020-07-28 /pmc/articles/PMC7435985/ /pubmed/32731449 http://dx.doi.org/10.3390/s20154189 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manwar, Rayyan
Kratkiewicz, Karl
Avanaki, Kamran
Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study
title Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study
title_full Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study
title_fullStr Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study
title_full_unstemmed Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study
title_short Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study
title_sort investigation of the effect of the skull in transcranial photoacoustic imaging: a preliminary ex vivo study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435985/
https://www.ncbi.nlm.nih.gov/pubmed/32731449
http://dx.doi.org/10.3390/s20154189
work_keys_str_mv AT manwarrayyan investigationoftheeffectoftheskullintranscranialphotoacousticimagingapreliminaryexvivostudy
AT kratkiewiczkarl investigationoftheeffectoftheskullintranscranialphotoacousticimagingapreliminaryexvivostudy
AT avanakikamran investigationoftheeffectoftheskullintranscranialphotoacousticimagingapreliminaryexvivostudy