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Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases
Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzymes. LOXs from higher eukaryotes are equipped with a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436259/ https://www.ncbi.nlm.nih.gov/pubmed/32722330 http://dx.doi.org/10.3390/molecules25153374 |
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author | Offenbacher, Adam R. Holman, Theodore R. |
author_facet | Offenbacher, Adam R. Holman, Theodore R. |
author_sort | Offenbacher, Adam R. |
collection | PubMed |
description | Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzymes. LOXs from higher eukaryotes are equipped with an N-terminal PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain that has been implicated to bind to small molecule allosteric effectors, which in turn modulate substrate specificity and the rate-limiting steps of catalysis. Herein, the kinetic and structural evidence that describes the allosteric regulation of plant and animal lipoxygenase chemistry by fatty acids and their derivatives are summarized. |
format | Online Article Text |
id | pubmed-7436259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74362592020-08-24 Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases Offenbacher, Adam R. Holman, Theodore R. Molecules Review Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzymes. LOXs from higher eukaryotes are equipped with an N-terminal PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain that has been implicated to bind to small molecule allosteric effectors, which in turn modulate substrate specificity and the rate-limiting steps of catalysis. Herein, the kinetic and structural evidence that describes the allosteric regulation of plant and animal lipoxygenase chemistry by fatty acids and their derivatives are summarized. MDPI 2020-07-24 /pmc/articles/PMC7436259/ /pubmed/32722330 http://dx.doi.org/10.3390/molecules25153374 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Offenbacher, Adam R. Holman, Theodore R. Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases |
title | Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases |
title_full | Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases |
title_fullStr | Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases |
title_full_unstemmed | Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases |
title_short | Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases |
title_sort | fatty acid allosteric regulation of c-h activation in plant and animal lipoxygenases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436259/ https://www.ncbi.nlm.nih.gov/pubmed/32722330 http://dx.doi.org/10.3390/molecules25153374 |
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