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Structural Characterization of Mono and Dihydroxylated Umbelliferone Derivatives

Coumarin derivatives are a class of compounds with a pronounced wide range of applications, especially in biological activities, in the medicine, pharmacology, cosmetics, coatings and food industry. Their potential applications are highly dependent on the nature of the substituents attached to their...

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Detalles Bibliográficos
Autores principales: Seoane-Rivero, Rubén, Ruiz-Bilbao, Estibaliz, Navarro, Rodrigo, Laza, José Manuel, Cuevas, José María, Artetxe, Beñat, Gutiérrez-Zorrilla, Juan M., Vilas-Vilela, José Luis, Marcos-Fernandez, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436329/
https://www.ncbi.nlm.nih.gov/pubmed/32751979
http://dx.doi.org/10.3390/molecules25153497
Descripción
Sumario:Coumarin derivatives are a class of compounds with a pronounced wide range of applications, especially in biological activities, in the medicine, pharmacology, cosmetics, coatings and food industry. Their potential applications are highly dependent on the nature of the substituents attached to their nucleus. These substituents modulate their photochemical and photophysical properties, as well as their interactions in their crystalline form, which largely determines the final field of application. Therefore, in this work a series of mono and dihydroxylated coumarin derivatives with different chemical substituents were synthesized and characterized by UV-Visible spectroscopy, thermal analysis (differential scanning calorimetry (DSC) and TGA), (1)H NMR and X-Ray Diffraction to identify limitations and possibilities as a function of the molecular structure for expanding their applications in polymer science.