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Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19

BACKGROUND: Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. METHODS: This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVI...

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Autores principales: Tai, Shi, Tang, Jianjun, Yu, Bilian, Tang, Liang, Wang, Yang, Zhang, Huilin, Zhu, Weihong, Xiao, Kui, Wen, Chuan, Tan, Chongqin, Jiang, Zhongbiao, Jiang, Chuanhao, Zhu, Li, Jiang, Li, Liu, Qiming, Hu, Xinqun, Fang, Zhenfei, Li, Xuping, Sun, Jiaxing, Zhu, Zhaowei, Yang, Hui, Tu, Tao, Xiao, Yichao, Chen, Mingxian, He, Yuhu, Chai, Xiangping, Xu, Junmei, Zhou, Shenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436340/
https://www.ncbi.nlm.nih.gov/pubmed/32874203
http://dx.doi.org/10.1155/2020/9059562
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author Tai, Shi
Tang, Jianjun
Yu, Bilian
Tang, Liang
Wang, Yang
Zhang, Huilin
Zhu, Weihong
Xiao, Kui
Wen, Chuan
Tan, Chongqin
Jiang, Zhongbiao
Jiang, Chuanhao
Zhu, Li
Jiang, Li
Liu, Qiming
Hu, Xinqun
Fang, Zhenfei
Li, Xuping
Sun, Jiaxing
Zhu, Zhaowei
Yang, Hui
Tu, Tao
Xiao, Yichao
Chen, Mingxian
He, Yuhu
Chai, Xiangping
Xu, Junmei
Zhou, Shenghua
author_facet Tai, Shi
Tang, Jianjun
Yu, Bilian
Tang, Liang
Wang, Yang
Zhang, Huilin
Zhu, Weihong
Xiao, Kui
Wen, Chuan
Tan, Chongqin
Jiang, Zhongbiao
Jiang, Chuanhao
Zhu, Li
Jiang, Li
Liu, Qiming
Hu, Xinqun
Fang, Zhenfei
Li, Xuping
Sun, Jiaxing
Zhu, Zhaowei
Yang, Hui
Tu, Tao
Xiao, Yichao
Chen, Mingxian
He, Yuhu
Chai, Xiangping
Xu, Junmei
Zhou, Shenghua
author_sort Tai, Shi
collection PubMed
description BACKGROUND: Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. METHODS: This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVID-19. The primary outcome was the need to be transferred to the designated hospital for intensive care due to COVID-19 disease progression. The patients were divided into with and without CV conditions as well as stable and intensive care groups. RESULTS: Of the 332 patients with mild COVID-19, the median age was 51 years (IQR, 40-59 years), and 200 (61.2%) were female. Of the 48 (14.5%) patients with CV conditions, 23 (47.9%) progressed to severe disease status and required intensive care. Compared with patients without CV conditions, patients with CV conditions were older and more likely to have fatigue, chest tightness, and myalgia. The rate of requiring intensive care was significantly higher among patients with CV conditions than in patients without CV conditions (47.92% vs. 12.4%; P < 0.001). In subgroup analysis, the rate of requiring intensive care was also higher among patients with either hypertension or coronary heart disease (CHD) than in patients without hypertension or CHD. The multivariable regression model showed that CV condition served as an independent risk factor for intensive care (odds ratio (OR), 2.652 (95% CI, 1.019-6.899)) after adjustment for various cofounders. CONCLUSIONS: Patients with mild COVID-19 complicating CV conditions are susceptible to develop severe disease status and requirement for intensive care.
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spelling pubmed-74363402020-08-31 Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19 Tai, Shi Tang, Jianjun Yu, Bilian Tang, Liang Wang, Yang Zhang, Huilin Zhu, Weihong Xiao, Kui Wen, Chuan Tan, Chongqin Jiang, Zhongbiao Jiang, Chuanhao Zhu, Li Jiang, Li Liu, Qiming Hu, Xinqun Fang, Zhenfei Li, Xuping Sun, Jiaxing Zhu, Zhaowei Yang, Hui Tu, Tao Xiao, Yichao Chen, Mingxian He, Yuhu Chai, Xiangping Xu, Junmei Zhou, Shenghua Cardiovasc Ther Research Article BACKGROUND: Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. METHODS: This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVID-19. The primary outcome was the need to be transferred to the designated hospital for intensive care due to COVID-19 disease progression. The patients were divided into with and without CV conditions as well as stable and intensive care groups. RESULTS: Of the 332 patients with mild COVID-19, the median age was 51 years (IQR, 40-59 years), and 200 (61.2%) were female. Of the 48 (14.5%) patients with CV conditions, 23 (47.9%) progressed to severe disease status and required intensive care. Compared with patients without CV conditions, patients with CV conditions were older and more likely to have fatigue, chest tightness, and myalgia. The rate of requiring intensive care was significantly higher among patients with CV conditions than in patients without CV conditions (47.92% vs. 12.4%; P < 0.001). In subgroup analysis, the rate of requiring intensive care was also higher among patients with either hypertension or coronary heart disease (CHD) than in patients without hypertension or CHD. The multivariable regression model showed that CV condition served as an independent risk factor for intensive care (odds ratio (OR), 2.652 (95% CI, 1.019-6.899)) after adjustment for various cofounders. CONCLUSIONS: Patients with mild COVID-19 complicating CV conditions are susceptible to develop severe disease status and requirement for intensive care. Hindawi 2020-08-01 /pmc/articles/PMC7436340/ /pubmed/32874203 http://dx.doi.org/10.1155/2020/9059562 Text en Copyright © 2020 Shi Tai et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tai, Shi
Tang, Jianjun
Yu, Bilian
Tang, Liang
Wang, Yang
Zhang, Huilin
Zhu, Weihong
Xiao, Kui
Wen, Chuan
Tan, Chongqin
Jiang, Zhongbiao
Jiang, Chuanhao
Zhu, Li
Jiang, Li
Liu, Qiming
Hu, Xinqun
Fang, Zhenfei
Li, Xuping
Sun, Jiaxing
Zhu, Zhaowei
Yang, Hui
Tu, Tao
Xiao, Yichao
Chen, Mingxian
He, Yuhu
Chai, Xiangping
Xu, Junmei
Zhou, Shenghua
Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19
title Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19
title_full Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19
title_fullStr Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19
title_full_unstemmed Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19
title_short Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19
title_sort association between cardiovascular burden and requirement of intensive care among patients with mild covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436340/
https://www.ncbi.nlm.nih.gov/pubmed/32874203
http://dx.doi.org/10.1155/2020/9059562
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