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Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19
BACKGROUND: Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. METHODS: This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVI...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436340/ https://www.ncbi.nlm.nih.gov/pubmed/32874203 http://dx.doi.org/10.1155/2020/9059562 |
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author | Tai, Shi Tang, Jianjun Yu, Bilian Tang, Liang Wang, Yang Zhang, Huilin Zhu, Weihong Xiao, Kui Wen, Chuan Tan, Chongqin Jiang, Zhongbiao Jiang, Chuanhao Zhu, Li Jiang, Li Liu, Qiming Hu, Xinqun Fang, Zhenfei Li, Xuping Sun, Jiaxing Zhu, Zhaowei Yang, Hui Tu, Tao Xiao, Yichao Chen, Mingxian He, Yuhu Chai, Xiangping Xu, Junmei Zhou, Shenghua |
author_facet | Tai, Shi Tang, Jianjun Yu, Bilian Tang, Liang Wang, Yang Zhang, Huilin Zhu, Weihong Xiao, Kui Wen, Chuan Tan, Chongqin Jiang, Zhongbiao Jiang, Chuanhao Zhu, Li Jiang, Li Liu, Qiming Hu, Xinqun Fang, Zhenfei Li, Xuping Sun, Jiaxing Zhu, Zhaowei Yang, Hui Tu, Tao Xiao, Yichao Chen, Mingxian He, Yuhu Chai, Xiangping Xu, Junmei Zhou, Shenghua |
author_sort | Tai, Shi |
collection | PubMed |
description | BACKGROUND: Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. METHODS: This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVID-19. The primary outcome was the need to be transferred to the designated hospital for intensive care due to COVID-19 disease progression. The patients were divided into with and without CV conditions as well as stable and intensive care groups. RESULTS: Of the 332 patients with mild COVID-19, the median age was 51 years (IQR, 40-59 years), and 200 (61.2%) were female. Of the 48 (14.5%) patients with CV conditions, 23 (47.9%) progressed to severe disease status and required intensive care. Compared with patients without CV conditions, patients with CV conditions were older and more likely to have fatigue, chest tightness, and myalgia. The rate of requiring intensive care was significantly higher among patients with CV conditions than in patients without CV conditions (47.92% vs. 12.4%; P < 0.001). In subgroup analysis, the rate of requiring intensive care was also higher among patients with either hypertension or coronary heart disease (CHD) than in patients without hypertension or CHD. The multivariable regression model showed that CV condition served as an independent risk factor for intensive care (odds ratio (OR), 2.652 (95% CI, 1.019-6.899)) after adjustment for various cofounders. CONCLUSIONS: Patients with mild COVID-19 complicating CV conditions are susceptible to develop severe disease status and requirement for intensive care. |
format | Online Article Text |
id | pubmed-7436340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-74363402020-08-31 Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19 Tai, Shi Tang, Jianjun Yu, Bilian Tang, Liang Wang, Yang Zhang, Huilin Zhu, Weihong Xiao, Kui Wen, Chuan Tan, Chongqin Jiang, Zhongbiao Jiang, Chuanhao Zhu, Li Jiang, Li Liu, Qiming Hu, Xinqun Fang, Zhenfei Li, Xuping Sun, Jiaxing Zhu, Zhaowei Yang, Hui Tu, Tao Xiao, Yichao Chen, Mingxian He, Yuhu Chai, Xiangping Xu, Junmei Zhou, Shenghua Cardiovasc Ther Research Article BACKGROUND: Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. METHODS: This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVID-19. The primary outcome was the need to be transferred to the designated hospital for intensive care due to COVID-19 disease progression. The patients were divided into with and without CV conditions as well as stable and intensive care groups. RESULTS: Of the 332 patients with mild COVID-19, the median age was 51 years (IQR, 40-59 years), and 200 (61.2%) were female. Of the 48 (14.5%) patients with CV conditions, 23 (47.9%) progressed to severe disease status and required intensive care. Compared with patients without CV conditions, patients with CV conditions were older and more likely to have fatigue, chest tightness, and myalgia. The rate of requiring intensive care was significantly higher among patients with CV conditions than in patients without CV conditions (47.92% vs. 12.4%; P < 0.001). In subgroup analysis, the rate of requiring intensive care was also higher among patients with either hypertension or coronary heart disease (CHD) than in patients without hypertension or CHD. The multivariable regression model showed that CV condition served as an independent risk factor for intensive care (odds ratio (OR), 2.652 (95% CI, 1.019-6.899)) after adjustment for various cofounders. CONCLUSIONS: Patients with mild COVID-19 complicating CV conditions are susceptible to develop severe disease status and requirement for intensive care. Hindawi 2020-08-01 /pmc/articles/PMC7436340/ /pubmed/32874203 http://dx.doi.org/10.1155/2020/9059562 Text en Copyright © 2020 Shi Tai et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tai, Shi Tang, Jianjun Yu, Bilian Tang, Liang Wang, Yang Zhang, Huilin Zhu, Weihong Xiao, Kui Wen, Chuan Tan, Chongqin Jiang, Zhongbiao Jiang, Chuanhao Zhu, Li Jiang, Li Liu, Qiming Hu, Xinqun Fang, Zhenfei Li, Xuping Sun, Jiaxing Zhu, Zhaowei Yang, Hui Tu, Tao Xiao, Yichao Chen, Mingxian He, Yuhu Chai, Xiangping Xu, Junmei Zhou, Shenghua Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19 |
title | Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19 |
title_full | Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19 |
title_fullStr | Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19 |
title_full_unstemmed | Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19 |
title_short | Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19 |
title_sort | association between cardiovascular burden and requirement of intensive care among patients with mild covid-19 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436340/ https://www.ncbi.nlm.nih.gov/pubmed/32874203 http://dx.doi.org/10.1155/2020/9059562 |
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