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A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery

Primary peritoneal carcinosarcomas which arise from extragenital locations are extremely rare. Carinosarcomas contain both carcinomatous and sarcomatous elements and can be mainly detected in the female genital tract. We herein report a case of primary peritoneal carcinosarcoma diagnosed by laparosc...

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Autores principales: Nagamata, Satoshi, Nakasuji, Yukiko, Yamanaka, Keitaro, Azumi, Maho, Washio, Keiichi, Shimizu, Maho, Takahashi, Ryosuke, Matsumoto, Kazuyo, Murata, Yuka, Suzuki, Kaho, Deguchi, Masashi, Yamada, Hideto, Terai, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436359/
https://www.ncbi.nlm.nih.gov/pubmed/32850164
http://dx.doi.org/10.1155/2020/9106390
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author Nagamata, Satoshi
Nakasuji, Yukiko
Yamanaka, Keitaro
Azumi, Maho
Washio, Keiichi
Shimizu, Maho
Takahashi, Ryosuke
Matsumoto, Kazuyo
Murata, Yuka
Suzuki, Kaho
Deguchi, Masashi
Yamada, Hideto
Terai, Yoshito
author_facet Nagamata, Satoshi
Nakasuji, Yukiko
Yamanaka, Keitaro
Azumi, Maho
Washio, Keiichi
Shimizu, Maho
Takahashi, Ryosuke
Matsumoto, Kazuyo
Murata, Yuka
Suzuki, Kaho
Deguchi, Masashi
Yamada, Hideto
Terai, Yoshito
author_sort Nagamata, Satoshi
collection PubMed
description Primary peritoneal carcinosarcomas which arise from extragenital locations are extremely rare. Carinosarcomas contain both carcinomatous and sarcomatous elements and can be mainly detected in the female genital tract. We herein report a case of primary peritoneal carcinosarcoma diagnosed by laparoscopic surgery and treated with olaparib. A 62-year-old woman referred to our hospital due to abdominal distension. From imaging findings, we suspected advanced primary peritoneal carcinoma, and laparoscopic surgery was thereafter performed. The pathological diagnosis was carcinosarcoma, and the patient received chemotherapy with docetaxel and carboplatin. After three cycles of chemotherapy, the interval debulking surgery was attempted but resulted in suboptimal results. Because the bilateral ovaries were observed with a normal size and normal findings, we considered that the most likely diagnosis was primary peritoneal carcinosarcoma. After the additional chemotherapy and a 6-month observation period, the tumor relapsed. The patient received chemotherapy again, and the peritoneal carcinosarcoma was judged to be a platinum-sensitive tumor. Oral administration of olaparib was thus initiated. Although a dose reduction was needed due to anemia, olaparib was effective, and the patient could continue the drug for another 7 months. This is the first report of primary peritoneal carcinosarcoma treated with olaparib and shows that it could be a treatment option for platinum-sensitive tumors.
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spelling pubmed-74363592020-08-25 A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery Nagamata, Satoshi Nakasuji, Yukiko Yamanaka, Keitaro Azumi, Maho Washio, Keiichi Shimizu, Maho Takahashi, Ryosuke Matsumoto, Kazuyo Murata, Yuka Suzuki, Kaho Deguchi, Masashi Yamada, Hideto Terai, Yoshito Case Rep Obstet Gynecol Case Report Primary peritoneal carcinosarcomas which arise from extragenital locations are extremely rare. Carinosarcomas contain both carcinomatous and sarcomatous elements and can be mainly detected in the female genital tract. We herein report a case of primary peritoneal carcinosarcoma diagnosed by laparoscopic surgery and treated with olaparib. A 62-year-old woman referred to our hospital due to abdominal distension. From imaging findings, we suspected advanced primary peritoneal carcinoma, and laparoscopic surgery was thereafter performed. The pathological diagnosis was carcinosarcoma, and the patient received chemotherapy with docetaxel and carboplatin. After three cycles of chemotherapy, the interval debulking surgery was attempted but resulted in suboptimal results. Because the bilateral ovaries were observed with a normal size and normal findings, we considered that the most likely diagnosis was primary peritoneal carcinosarcoma. After the additional chemotherapy and a 6-month observation period, the tumor relapsed. The patient received chemotherapy again, and the peritoneal carcinosarcoma was judged to be a platinum-sensitive tumor. Oral administration of olaparib was thus initiated. Although a dose reduction was needed due to anemia, olaparib was effective, and the patient could continue the drug for another 7 months. This is the first report of primary peritoneal carcinosarcoma treated with olaparib and shows that it could be a treatment option for platinum-sensitive tumors. Hindawi 2020-08-10 /pmc/articles/PMC7436359/ /pubmed/32850164 http://dx.doi.org/10.1155/2020/9106390 Text en Copyright © 2020 Satoshi Nagamata et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nagamata, Satoshi
Nakasuji, Yukiko
Yamanaka, Keitaro
Azumi, Maho
Washio, Keiichi
Shimizu, Maho
Takahashi, Ryosuke
Matsumoto, Kazuyo
Murata, Yuka
Suzuki, Kaho
Deguchi, Masashi
Yamada, Hideto
Terai, Yoshito
A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery
title A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery
title_full A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery
title_fullStr A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery
title_full_unstemmed A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery
title_short A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery
title_sort case of significant response to olaparib in a patient with primary peritoneal carcinosarcoma diagnosed by laparoscopic surgery
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436359/
https://www.ncbi.nlm.nih.gov/pubmed/32850164
http://dx.doi.org/10.1155/2020/9106390
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