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A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand
INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID‐19). The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition suc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436537/ https://www.ncbi.nlm.nih.gov/pubmed/32770646 http://dx.doi.org/10.1002/iid3.337 |
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author | Sakulkonkij, Parichart Bruminhent, Jackrapong Pankongngam, Charan Chalermphunchai, Nipon |
author_facet | Sakulkonkij, Parichart Bruminhent, Jackrapong Pankongngam, Charan Chalermphunchai, Nipon |
author_sort | Sakulkonkij, Parichart |
collection | PubMed |
description | INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID‐19). The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition such as solid organ transplant recipients. METHOD: We described a family cluster of COVID‐19 patients who were admitted during 3rd April 2020 to 30th April 2020. COVID‐19 was confirmed by a presence of SARS‐CoV‐2 ribonucleic acid in the respiratory specimens detected by a qualitative, real‐time reverse transcription‐polymerase chain reaction. The study focused on the clinical course and management of our cases. RESULTS: A family cluster of four laboratory‐confirmed COVID‐19 patients, one of those carried an underlying kidney transplant (KT) receiving immunosuppressants. Clinical presentation and severity of our case series are variable depending on each individual immune status. By far, a KT recipient seems to develop more severity despite antiviral therapy, cessation of immunosuppressant, and aggressive intensive care support. CONCLUSION: Our case series plausibly affirmed a person‐to‐person transmission and potentially severe disease in the transplant population. Clinicians who are encountering with transplant recipients should be aware of possible transmission among family members. |
format | Online Article Text |
id | pubmed-7436537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74365372020-08-19 A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand Sakulkonkij, Parichart Bruminhent, Jackrapong Pankongngam, Charan Chalermphunchai, Nipon Immun Inflamm Dis Original Research INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID‐19). The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition such as solid organ transplant recipients. METHOD: We described a family cluster of COVID‐19 patients who were admitted during 3rd April 2020 to 30th April 2020. COVID‐19 was confirmed by a presence of SARS‐CoV‐2 ribonucleic acid in the respiratory specimens detected by a qualitative, real‐time reverse transcription‐polymerase chain reaction. The study focused on the clinical course and management of our cases. RESULTS: A family cluster of four laboratory‐confirmed COVID‐19 patients, one of those carried an underlying kidney transplant (KT) receiving immunosuppressants. Clinical presentation and severity of our case series are variable depending on each individual immune status. By far, a KT recipient seems to develop more severity despite antiviral therapy, cessation of immunosuppressant, and aggressive intensive care support. CONCLUSION: Our case series plausibly affirmed a person‐to‐person transmission and potentially severe disease in the transplant population. Clinicians who are encountering with transplant recipients should be aware of possible transmission among family members. John Wiley and Sons Inc. 2020-08-08 /pmc/articles/PMC7436537/ /pubmed/32770646 http://dx.doi.org/10.1002/iid3.337 Text en © 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Sakulkonkij, Parichart Bruminhent, Jackrapong Pankongngam, Charan Chalermphunchai, Nipon A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand |
title | A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand |
title_full | A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand |
title_fullStr | A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand |
title_full_unstemmed | A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand |
title_short | A family cluster of diagnosed coronavirus disease 2019 (COVID‐19) kidney transplant recipient in Thailand |
title_sort | family cluster of diagnosed coronavirus disease 2019 (covid‐19) kidney transplant recipient in thailand |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436537/ https://www.ncbi.nlm.nih.gov/pubmed/32770646 http://dx.doi.org/10.1002/iid3.337 |
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