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Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H(2)S donors in COVID‐19 therapy

The COVID‐19 pandemic caused by SARS‐Cov‐2 demands rapid, safe and effective therapeutic options. In the last decades, the endogenous gasotransmitter hydrogen sulfide (H(2)S) has emerged as modulator of several biological functions and its deficiency has been associated with different disorders. The...

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Autores principales: Citi, Valentina, Martelli, Alma, Brancaleone, Vincenzo, Brogi, Simone, Gojon, Gabriel, Montanaro, Rosangela, Morales, Guillermo, Testai, Lara, Calderone, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436626/
https://www.ncbi.nlm.nih.gov/pubmed/32783196
http://dx.doi.org/10.1111/bph.15230
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author Citi, Valentina
Martelli, Alma
Brancaleone, Vincenzo
Brogi, Simone
Gojon, Gabriel
Montanaro, Rosangela
Morales, Guillermo
Testai, Lara
Calderone, Vincenzo
author_facet Citi, Valentina
Martelli, Alma
Brancaleone, Vincenzo
Brogi, Simone
Gojon, Gabriel
Montanaro, Rosangela
Morales, Guillermo
Testai, Lara
Calderone, Vincenzo
author_sort Citi, Valentina
collection PubMed
description The COVID‐19 pandemic caused by SARS‐Cov‐2 demands rapid, safe and effective therapeutic options. In the last decades, the endogenous gasotransmitter hydrogen sulfide (H(2)S) has emerged as modulator of several biological functions and its deficiency has been associated with different disorders. Therefore, many H(2)S‐releasing agents have been developed as potential therapeutic tools for diseases related with impaired H(2)S production and/or activity. Some of these compounds are in advanced clinical trials. Presently, the pivotal role of H(2)S in modulating the inflammatory response and pro‐inflammatory cytokine cascade is well recognized, and the usefulness of some H(2)S‐donors for the treatment of acute lung inflammation has been reported. Recent data is elucidating several mechanisms of action, which may account for antiviral effects of H(2)S. Noteworthy, some preliminary clinical results suggest an inverse relationship between endogenous H(2)S levels and severity of COVID‐19. Therefore, repurposing of H(2)S‐releasing drugs may be a potential therapeutic opportunity for treatment of COVID‐19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID‐19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc
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spelling pubmed-74366262020-08-19 Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H(2)S donors in COVID‐19 therapy Citi, Valentina Martelli, Alma Brancaleone, Vincenzo Brogi, Simone Gojon, Gabriel Montanaro, Rosangela Morales, Guillermo Testai, Lara Calderone, Vincenzo Br J Pharmacol Themed Issue: Review Articles The COVID‐19 pandemic caused by SARS‐Cov‐2 demands rapid, safe and effective therapeutic options. In the last decades, the endogenous gasotransmitter hydrogen sulfide (H(2)S) has emerged as modulator of several biological functions and its deficiency has been associated with different disorders. Therefore, many H(2)S‐releasing agents have been developed as potential therapeutic tools for diseases related with impaired H(2)S production and/or activity. Some of these compounds are in advanced clinical trials. Presently, the pivotal role of H(2)S in modulating the inflammatory response and pro‐inflammatory cytokine cascade is well recognized, and the usefulness of some H(2)S‐donors for the treatment of acute lung inflammation has been reported. Recent data is elucidating several mechanisms of action, which may account for antiviral effects of H(2)S. Noteworthy, some preliminary clinical results suggest an inverse relationship between endogenous H(2)S levels and severity of COVID‐19. Therefore, repurposing of H(2)S‐releasing drugs may be a potential therapeutic opportunity for treatment of COVID‐19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID‐19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc John Wiley and Sons Inc. 2020-08-26 2020-11 /pmc/articles/PMC7436626/ /pubmed/32783196 http://dx.doi.org/10.1111/bph.15230 Text en © 2020 The British Pharmacological Society
spellingShingle Themed Issue: Review Articles
Citi, Valentina
Martelli, Alma
Brancaleone, Vincenzo
Brogi, Simone
Gojon, Gabriel
Montanaro, Rosangela
Morales, Guillermo
Testai, Lara
Calderone, Vincenzo
Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H(2)S donors in COVID‐19 therapy
title Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H(2)S donors in COVID‐19 therapy
title_full Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H(2)S donors in COVID‐19 therapy
title_fullStr Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H(2)S donors in COVID‐19 therapy
title_full_unstemmed Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H(2)S donors in COVID‐19 therapy
title_short Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H(2)S donors in COVID‐19 therapy
title_sort anti‐inflammatory and antiviral roles of hydrogen sulfide: rationale for considering h(2)s donors in covid‐19 therapy
topic Themed Issue: Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436626/
https://www.ncbi.nlm.nih.gov/pubmed/32783196
http://dx.doi.org/10.1111/bph.15230
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