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Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel

Fournier’s gangrene (FG) is an uncommon form of necrotizing fasciitis, localized on the external genital organs, perianal region, and abdominal wall, accompanied by thrombosis of the feeding arteries, leading to gangrene of the skin and subcutaneous tissue, with manifestations of rapid clinical prog...

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Detalles Bibliográficos
Autores principales: Rakusic, Zoran, Krpan, Ana Misir, Sjekavica, Ivica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436778/
https://www.ncbi.nlm.nih.gov/pubmed/32874533
http://dx.doi.org/10.1177/2042098620946556
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author Rakusic, Zoran
Krpan, Ana Misir
Sjekavica, Ivica
author_facet Rakusic, Zoran
Krpan, Ana Misir
Sjekavica, Ivica
author_sort Rakusic, Zoran
collection PubMed
description Fournier’s gangrene (FG) is an uncommon form of necrotizing fasciitis, localized on the external genital organs, perianal region, and abdominal wall, accompanied by thrombosis of the feeding arteries, leading to gangrene of the skin and subcutaneous tissue, with manifestations of rapid clinical progression and multiple organ failure. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of vascular endothelial growth factor receptor-2 (VEGFR-2) and prevents the binding of all VEGFR ligands. The literature describes bevacizumab, aflibercept, and regorafenib associated with FG in patients with colorectal cancer. According to our knowledge this is the first report of FG possibly related to ramucirumab in a patient with gastric cancer. If not recognized in time, it can lead to fatal complications.
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spelling pubmed-74367782020-08-31 Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel Rakusic, Zoran Krpan, Ana Misir Sjekavica, Ivica Ther Adv Drug Saf Case Report Fournier’s gangrene (FG) is an uncommon form of necrotizing fasciitis, localized on the external genital organs, perianal region, and abdominal wall, accompanied by thrombosis of the feeding arteries, leading to gangrene of the skin and subcutaneous tissue, with manifestations of rapid clinical progression and multiple organ failure. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of vascular endothelial growth factor receptor-2 (VEGFR-2) and prevents the binding of all VEGFR ligands. The literature describes bevacizumab, aflibercept, and regorafenib associated with FG in patients with colorectal cancer. According to our knowledge this is the first report of FG possibly related to ramucirumab in a patient with gastric cancer. If not recognized in time, it can lead to fatal complications. SAGE Publications 2020-08-17 /pmc/articles/PMC7436778/ /pubmed/32874533 http://dx.doi.org/10.1177/2042098620946556 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Rakusic, Zoran
Krpan, Ana Misir
Sjekavica, Ivica
Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel
title Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel
title_full Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel
title_fullStr Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel
title_full_unstemmed Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel
title_short Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel
title_sort fulminant fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436778/
https://www.ncbi.nlm.nih.gov/pubmed/32874533
http://dx.doi.org/10.1177/2042098620946556
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