Cargando…
Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel
Fournier’s gangrene (FG) is an uncommon form of necrotizing fasciitis, localized on the external genital organs, perianal region, and abdominal wall, accompanied by thrombosis of the feeding arteries, leading to gangrene of the skin and subcutaneous tissue, with manifestations of rapid clinical prog...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436778/ https://www.ncbi.nlm.nih.gov/pubmed/32874533 http://dx.doi.org/10.1177/2042098620946556 |
_version_ | 1783572544334331904 |
---|---|
author | Rakusic, Zoran Krpan, Ana Misir Sjekavica, Ivica |
author_facet | Rakusic, Zoran Krpan, Ana Misir Sjekavica, Ivica |
author_sort | Rakusic, Zoran |
collection | PubMed |
description | Fournier’s gangrene (FG) is an uncommon form of necrotizing fasciitis, localized on the external genital organs, perianal region, and abdominal wall, accompanied by thrombosis of the feeding arteries, leading to gangrene of the skin and subcutaneous tissue, with manifestations of rapid clinical progression and multiple organ failure. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of vascular endothelial growth factor receptor-2 (VEGFR-2) and prevents the binding of all VEGFR ligands. The literature describes bevacizumab, aflibercept, and regorafenib associated with FG in patients with colorectal cancer. According to our knowledge this is the first report of FG possibly related to ramucirumab in a patient with gastric cancer. If not recognized in time, it can lead to fatal complications. |
format | Online Article Text |
id | pubmed-7436778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-74367782020-08-31 Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel Rakusic, Zoran Krpan, Ana Misir Sjekavica, Ivica Ther Adv Drug Saf Case Report Fournier’s gangrene (FG) is an uncommon form of necrotizing fasciitis, localized on the external genital organs, perianal region, and abdominal wall, accompanied by thrombosis of the feeding arteries, leading to gangrene of the skin and subcutaneous tissue, with manifestations of rapid clinical progression and multiple organ failure. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of vascular endothelial growth factor receptor-2 (VEGFR-2) and prevents the binding of all VEGFR ligands. The literature describes bevacizumab, aflibercept, and regorafenib associated with FG in patients with colorectal cancer. According to our knowledge this is the first report of FG possibly related to ramucirumab in a patient with gastric cancer. If not recognized in time, it can lead to fatal complications. SAGE Publications 2020-08-17 /pmc/articles/PMC7436778/ /pubmed/32874533 http://dx.doi.org/10.1177/2042098620946556 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Rakusic, Zoran Krpan, Ana Misir Sjekavica, Ivica Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel |
title | Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel |
title_full | Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel |
title_fullStr | Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel |
title_full_unstemmed | Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel |
title_short | Fulminant Fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel |
title_sort | fulminant fournier’s gangrene in a patient with gastric cancer treated with ramucirumab and paclitaxel |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436778/ https://www.ncbi.nlm.nih.gov/pubmed/32874533 http://dx.doi.org/10.1177/2042098620946556 |
work_keys_str_mv | AT rakusiczoran fulminantfourniersgangreneinapatientwithgastriccancertreatedwithramucirumabandpaclitaxel AT krpananamisir fulminantfourniersgangreneinapatientwithgastriccancertreatedwithramucirumabandpaclitaxel AT sjekavicaivica fulminantfourniersgangreneinapatientwithgastriccancertreatedwithramucirumabandpaclitaxel |