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A rare case report of apixaban-induced lichenoid eruption
With recent increase in the use of direct oral anticoagulants (DOACs), several new cases of adverse drug reactions (ADRs) have been identified in pharmacovigilance surveys. These ADRs can result in significant mortality and morbidity if not identified and treated promptly. It is important for physic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436782/ https://www.ncbi.nlm.nih.gov/pubmed/32874531 http://dx.doi.org/10.1177/2042098620937884 |
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author | Patil, Tanvi Hanna, Suzanne Torre, Wayne |
author_facet | Patil, Tanvi Hanna, Suzanne Torre, Wayne |
author_sort | Patil, Tanvi |
collection | PubMed |
description | With recent increase in the use of direct oral anticoagulants (DOACs), several new cases of adverse drug reactions (ADRs) have been identified in pharmacovigilance surveys. These ADRs can result in significant mortality and morbidity if not identified and treated promptly. It is important for physicians to recognize that immunologically mediated delayed hypersensitivity reactions, although rare in occurrence, can have significant impact on patient’s quality of life. To the best of our knowledge, we report the first case of lichenoid eruption associated with apixaban. We further provide evidence of tolerance to rivaroxaban in the same patient. PLAIN LANGUAGE SUMMARY: Apixaban-induced lichenoid eruption Well documented case reports, although providing evidence of probable causal relationship between a drug and specific adverse drug reactions (ADRs), can increase awareness amongst clinicians treating patients with direct oral anticoagulants (DOACs), especially with its rapid utilization. Rare ADRs are difficult to detect as clinical trials of DOACs lacked enough patient sample, making post-marketing reporting of such events important so both patients and clinicians can be vigilant to help with prompt recognition of such symptoms. We report the first case of lichenoid eruption hypersensitivity reaction associated with apixaban in patient with tolerance to rivaroxaban. |
format | Online Article Text |
id | pubmed-7436782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-74367822020-08-31 A rare case report of apixaban-induced lichenoid eruption Patil, Tanvi Hanna, Suzanne Torre, Wayne Ther Adv Drug Saf Case Report With recent increase in the use of direct oral anticoagulants (DOACs), several new cases of adverse drug reactions (ADRs) have been identified in pharmacovigilance surveys. These ADRs can result in significant mortality and morbidity if not identified and treated promptly. It is important for physicians to recognize that immunologically mediated delayed hypersensitivity reactions, although rare in occurrence, can have significant impact on patient’s quality of life. To the best of our knowledge, we report the first case of lichenoid eruption associated with apixaban. We further provide evidence of tolerance to rivaroxaban in the same patient. PLAIN LANGUAGE SUMMARY: Apixaban-induced lichenoid eruption Well documented case reports, although providing evidence of probable causal relationship between a drug and specific adverse drug reactions (ADRs), can increase awareness amongst clinicians treating patients with direct oral anticoagulants (DOACs), especially with its rapid utilization. Rare ADRs are difficult to detect as clinical trials of DOACs lacked enough patient sample, making post-marketing reporting of such events important so both patients and clinicians can be vigilant to help with prompt recognition of such symptoms. We report the first case of lichenoid eruption hypersensitivity reaction associated with apixaban in patient with tolerance to rivaroxaban. SAGE Publications 2020-08-17 /pmc/articles/PMC7436782/ /pubmed/32874531 http://dx.doi.org/10.1177/2042098620937884 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Patil, Tanvi Hanna, Suzanne Torre, Wayne A rare case report of apixaban-induced lichenoid eruption |
title | A rare case report of apixaban-induced lichenoid eruption |
title_full | A rare case report of apixaban-induced lichenoid eruption |
title_fullStr | A rare case report of apixaban-induced lichenoid eruption |
title_full_unstemmed | A rare case report of apixaban-induced lichenoid eruption |
title_short | A rare case report of apixaban-induced lichenoid eruption |
title_sort | rare case report of apixaban-induced lichenoid eruption |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436782/ https://www.ncbi.nlm.nih.gov/pubmed/32874531 http://dx.doi.org/10.1177/2042098620937884 |
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