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P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

BACKGROUND: Neuronal accumulation of misfolded microtubule-associated protein tau is a hallmark of neuropathology in Alzheimer’s disease, frontotemporal dementia, and other tauopathies, and has been a therapeutic target. Microglia can spread tau pathology by secreting tau-containing exosomes, althou...

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Detalles Bibliográficos
Autores principales:	Ruan, Zhi, Delpech, Jean-Christophe, Venkatesan Kalavai, Srinidhi, Van Enoo, Alicia A., Hu, Jianqiao, Ikezu, Seiko, Ikezu, Tsuneya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436984/ https://www.ncbi.nlm.nih.gov/pubmed/32811520 http://dx.doi.org/10.1186/s13024-020-00396-2

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