Cargando…

The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea

The aging of the brain is a well-investigated topic, but existing analyses have mainly focused on Caucasian samples. To investigate brain aging in East Asians, we measured cortical and subcortical volumes from magnetic resonance imaging (MRI) scans of 1,008 cognitively normal elderly Koreans from th...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Yu Yong, Lee, Jang Jae, Choi, Kyu Yeong, Seo, Eun Hyun, Choo, IL Han, Kim, Hoowon, Song, Min-Kyung, Choi, Seong-Min, Cho, Soo Hyun, Kim, Byeong C., Lee, Kun Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437271/
https://www.ncbi.nlm.nih.gov/pubmed/32903525
http://dx.doi.org/10.3389/fnagi.2020.00233
_version_ 1783572609729822720
author Choi, Yu Yong
Lee, Jang Jae
Choi, Kyu Yeong
Seo, Eun Hyun
Choo, IL Han
Kim, Hoowon
Song, Min-Kyung
Choi, Seong-Min
Cho, Soo Hyun
Kim, Byeong C.
Lee, Kun Ho
author_facet Choi, Yu Yong
Lee, Jang Jae
Choi, Kyu Yeong
Seo, Eun Hyun
Choo, IL Han
Kim, Hoowon
Song, Min-Kyung
Choi, Seong-Min
Cho, Soo Hyun
Kim, Byeong C.
Lee, Kun Ho
author_sort Choi, Yu Yong
collection PubMed
description The aging of the brain is a well-investigated topic, but existing analyses have mainly focused on Caucasian samples. To investigate brain aging in East Asians, we measured cortical and subcortical volumes from magnetic resonance imaging (MRI) scans of 1,008 cognitively normal elderly Koreans from the Gwangju Alzheimer’s and Related Dementia cohort and 342 Caucasians from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. To determine whether the aging effect varies with ethnicity and sex, beta coefficients of age and confidence intervals (CIs) were estimated in each ethnicity–sex group using a bootstrap method and a regression analysis using the relative volume to intracranial volume as predicted. The betas or aging slopes largely were not significantly different between ethnicity and sex groups in most types of brain structures. However, ethnic differences between the two female groups were found in the brain, most cortical regions, and a few subcortical regions. Ethnic differences in brain aging are likely due in large part to genetic factors; thus, we compared carriers and non-carriers of a gene relevant to longevity and neurodegenerative diseases, such as apolipoprotein E (APOE) ε4. The regions with ethnic differences in women also showed significant differences between Korean APOE ε4 non-carriers and Caucasian APOE ε4 carriers. Furthermore, Caucasian women showed significant APOE ε4 effects in the largest number of regions. These results illustrate that much of the ethnic differences in females may be explained by synergistic effects of ethnic background and APOE ε4 carrier status. Our results suggest that sex-dependent differences of aging between ethnic backgrounds may be due to ethnicity-dependent effects of genetic risk factors, such as APOE ε4. We also presented the normative information on volume estimates of the brain structures of the elderly Korean people in the subdivided age groups. This normative information of the aging brain stratified by ethnicity provides the age-related reference ranges quantified to replace visual judgment and facilitate precise clinical decision-making.
format Online
Article
Text
id pubmed-7437271
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-74372712020-09-03 The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea Choi, Yu Yong Lee, Jang Jae Choi, Kyu Yeong Seo, Eun Hyun Choo, IL Han Kim, Hoowon Song, Min-Kyung Choi, Seong-Min Cho, Soo Hyun Kim, Byeong C. Lee, Kun Ho Front Aging Neurosci Neuroscience The aging of the brain is a well-investigated topic, but existing analyses have mainly focused on Caucasian samples. To investigate brain aging in East Asians, we measured cortical and subcortical volumes from magnetic resonance imaging (MRI) scans of 1,008 cognitively normal elderly Koreans from the Gwangju Alzheimer’s and Related Dementia cohort and 342 Caucasians from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. To determine whether the aging effect varies with ethnicity and sex, beta coefficients of age and confidence intervals (CIs) were estimated in each ethnicity–sex group using a bootstrap method and a regression analysis using the relative volume to intracranial volume as predicted. The betas or aging slopes largely were not significantly different between ethnicity and sex groups in most types of brain structures. However, ethnic differences between the two female groups were found in the brain, most cortical regions, and a few subcortical regions. Ethnic differences in brain aging are likely due in large part to genetic factors; thus, we compared carriers and non-carriers of a gene relevant to longevity and neurodegenerative diseases, such as apolipoprotein E (APOE) ε4. The regions with ethnic differences in women also showed significant differences between Korean APOE ε4 non-carriers and Caucasian APOE ε4 carriers. Furthermore, Caucasian women showed significant APOE ε4 effects in the largest number of regions. These results illustrate that much of the ethnic differences in females may be explained by synergistic effects of ethnic background and APOE ε4 carrier status. Our results suggest that sex-dependent differences of aging between ethnic backgrounds may be due to ethnicity-dependent effects of genetic risk factors, such as APOE ε4. We also presented the normative information on volume estimates of the brain structures of the elderly Korean people in the subdivided age groups. This normative information of the aging brain stratified by ethnicity provides the age-related reference ranges quantified to replace visual judgment and facilitate precise clinical decision-making. Frontiers Media S.A. 2020-08-12 /pmc/articles/PMC7437271/ /pubmed/32903525 http://dx.doi.org/10.3389/fnagi.2020.00233 Text en Copyright © 2020 Choi, Lee, Choi, Seo, Choo, Kim, Song, Choi, Cho, Kim and Lee. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Choi, Yu Yong
Lee, Jang Jae
Choi, Kyu Yeong
Seo, Eun Hyun
Choo, IL Han
Kim, Hoowon
Song, Min-Kyung
Choi, Seong-Min
Cho, Soo Hyun
Kim, Byeong C.
Lee, Kun Ho
The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea
title The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea
title_full The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea
title_fullStr The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea
title_full_unstemmed The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea
title_short The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea
title_sort aging slopes of brain structures vary by ethnicity and sex: evidence from a large magnetic resonance imaging dataset from a single scanner of cognitively healthy elderly people in korea
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437271/
https://www.ncbi.nlm.nih.gov/pubmed/32903525
http://dx.doi.org/10.3389/fnagi.2020.00233
work_keys_str_mv AT choiyuyong theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT leejangjae theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT choikyuyeong theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT seoeunhyun theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT chooilhan theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT kimhoowon theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT songminkyung theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT choiseongmin theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT chosoohyun theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT kimbyeongc theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT leekunho theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT theagingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT choiyuyong agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT leejangjae agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT choikyuyeong agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT seoeunhyun agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT chooilhan agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT kimhoowon agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT songminkyung agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT choiseongmin agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT chosoohyun agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT kimbyeongc agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT leekunho agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea
AT agingslopesofbrainstructuresvarybyethnicityandsexevidencefromalargemagneticresonanceimagingdatasetfromasinglescannerofcognitivelyhealthyelderlypeopleinkorea