Predicting steady‐state endoxifen plasma concentrations in breast cancer patients by CYP2D6 genotyping or phenotyping. Which approach is more reliable?

In previous studies, steady‐state Z‐endoxifen plasma concentrations (ENDOss) correlated with relapse‐free survival in women on tamoxifen (TAM) treatment for breast cancer. ENDOss also correlated significantly with CYP2D6 genotype (activity score) and CYP2D6 phenotype (dextromethorphan test). Our aim...

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Detalles Bibliográficos
Autores principales: Gusella, Milena, Pasini, Felice, Corso, Barbara, Bertolaso, Laura, De Rosa, Giovanni, Falci, Cristina, Modena, Yasmina, Barile, Carmen, Da Corte Z, Donatella, Fraccon, AnnaPaola, Toso, Silvia, Cretella, Elisabetta, Brunello, Antonella, Modonesi, Caterina, Segati, Romana, Oliani, Cristina, Minicuci, Nadia, Padrini, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437348/
https://www.ncbi.nlm.nih.gov/pubmed/32813313
http://dx.doi.org/10.1002/prp2.646

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