Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

Sprouty-related, EVH1 domain-containing (SPRED) proteins negatively regulate RAS/mitogen-activated protein kinase (MAPK) signaling following growth factor stimulation. This inhibition of RAS is thought to occur primarily through SPRED1 binding and recruitment of neurofibromin, a RasGAP, to the plasm...

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Detalles Bibliográficos
Autores principales: Yan, Wupeng, Markegard, Evan, Dharmaiah, Srisathiyanarayanan, Urisman, Anatoly, Drew, Matthew, Esposito, Dominic, Scheffzek, Klaus, Nissley, Dwight V., McCormick, Frank, Simanshu, Dhirendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437355/
https://www.ncbi.nlm.nih.gov/pubmed/32697994
http://dx.doi.org/10.1016/j.celrep.2020.107909

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