Why PB28 Could Be a Covid 2019 Game Changer?

[Image: see text] PB28, a cyclohexylpiperazine derivative, could be a potential strategy for Covid 19 because in a recent study it has been found more active than hydroxychloroquine without interaction with cardiac proteins. PB28 has been designed, developed, and biologically evaluated in the past d...

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Detalles Bibliográficos
Autores principales: Colabufo, Nicola Antonio, Leopoldo, Marcello, Ferorelli, Savina, Abate, Carmen, Contino, Marialessandra, Perrone, Maria Grazia, Niso, Mauro, Perrone, Roberto, Berardi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437449/
https://www.ncbi.nlm.nih.gov/pubmed/33052254
http://dx.doi.org/10.1021/acsmedchemlett.0c00271
Descripción
Sumario:[Image: see text] PB28, a cyclohexylpiperazine derivative, could be a potential strategy for Covid 19 because in a recent study it has been found more active than hydroxychloroquine without interaction with cardiac proteins. PB28 has been designed, developed, and biologically evaluated in the past decade in our research group. A possible mechanism to explain its surprising anti-COVID-19 activity is suggested..

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