Why PB28 Could Be a Covid 2019 Game Changer?

[Image: see text] PB28, a cyclohexylpiperazine derivative, could be a potential strategy for Covid 19 because in a recent study it has been found more active than hydroxychloroquine without interaction with cardiac proteins. PB28 has been designed, developed, and biologically evaluated in the past d...

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Autores principales: Colabufo, Nicola Antonio, Leopoldo, Marcello, Ferorelli, Savina, Abate, Carmen, Contino, Marialessandra, Perrone, Maria Grazia, Niso, Mauro, Perrone, Roberto, Berardi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437449/
https://www.ncbi.nlm.nih.gov/pubmed/33052254
http://dx.doi.org/10.1021/acsmedchemlett.0c00271
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author Colabufo, Nicola Antonio
Leopoldo, Marcello
Ferorelli, Savina
Abate, Carmen
Contino, Marialessandra
Perrone, Maria Grazia
Niso, Mauro
Perrone, Roberto
Berardi, Francesco
author_facet Colabufo, Nicola Antonio
Leopoldo, Marcello
Ferorelli, Savina
Abate, Carmen
Contino, Marialessandra
Perrone, Maria Grazia
Niso, Mauro
Perrone, Roberto
Berardi, Francesco
author_sort Colabufo, Nicola Antonio
collection PubMed
description [Image: see text] PB28, a cyclohexylpiperazine derivative, could be a potential strategy for Covid 19 because in a recent study it has been found more active than hydroxychloroquine without interaction with cardiac proteins. PB28 has been designed, developed, and biologically evaluated in the past decade in our research group. A possible mechanism to explain its surprising anti-COVID-19 activity is suggested..
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spelling pubmed-74374492020-08-19 Why PB28 Could Be a Covid 2019 Game Changer? Colabufo, Nicola Antonio Leopoldo, Marcello Ferorelli, Savina Abate, Carmen Contino, Marialessandra Perrone, Maria Grazia Niso, Mauro Perrone, Roberto Berardi, Francesco ACS Med Chem Lett [Image: see text] PB28, a cyclohexylpiperazine derivative, could be a potential strategy for Covid 19 because in a recent study it has been found more active than hydroxychloroquine without interaction with cardiac proteins. PB28 has been designed, developed, and biologically evaluated in the past decade in our research group. A possible mechanism to explain its surprising anti-COVID-19 activity is suggested.. American Chemical Society 2020-08-14 /pmc/articles/PMC7437449/ /pubmed/33052254 http://dx.doi.org/10.1021/acsmedchemlett.0c00271 Text en This article is made available via the ACS COVID-19 subset (https://pubs.acs.org/page/vi/chemistry_coronavirus_research) for unrestricted RESEARCH re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Colabufo, Nicola Antonio
Leopoldo, Marcello
Ferorelli, Savina
Abate, Carmen
Contino, Marialessandra
Perrone, Maria Grazia
Niso, Mauro
Perrone, Roberto
Berardi, Francesco
Why PB28 Could Be a Covid 2019 Game Changer?
title Why PB28 Could Be a Covid 2019 Game Changer?
title_full Why PB28 Could Be a Covid 2019 Game Changer?
title_fullStr Why PB28 Could Be a Covid 2019 Game Changer?
title_full_unstemmed Why PB28 Could Be a Covid 2019 Game Changer?
title_short Why PB28 Could Be a Covid 2019 Game Changer?
title_sort why pb28 could be a covid 2019 game changer?
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437449/
https://www.ncbi.nlm.nih.gov/pubmed/33052254
http://dx.doi.org/10.1021/acsmedchemlett.0c00271
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