A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a chimpanzee adenovirus-vectored vaccine encoding a prefusion stabilized spike protein (ChAd-SARS-CoV-2-S) in challenge studies with severe acute respir...

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Detalles Bibliográficos
Autores principales: Hassan, Ahmed O., Kafai, Natasha M., Dmitriev, Igor P., Fox, Julie M., Smith, Brittany K., Harvey, Ian B., Chen, Rita E., Winkler, Emma S., Wessel, Alex W., Case, James Brett, Kashentseva, Elena, McCune, Broc T., Bailey, Adam L., Zhao, Haiyan, VanBlargan, Laura A., Dai, Ya-Nan, Ma, Meisheng, Adams, Lucas J., Shrihari, Swathi, Danis, Jonathan E., Gralinski, Lisa E., Hou, Yixuan J., Schäfer, Alexandra, Kim, Arthur S., Keeler, Shamus P., Weiskopf, Daniela, Baric, Ralph S., Holtzman, Michael J., Fremont, Daved H., Curiel, David T., Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437481/
https://www.ncbi.nlm.nih.gov/pubmed/32931734
http://dx.doi.org/10.1016/j.cell.2020.08.026

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