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Acute pancreatitis and nosocomial COVID-19: Cause specific host responses may determine lung injury
BACKGROUND: Coronavirus disease 2019 (COVID-19) presents with myriad extra-pulmonary manifestation and a high mortality in patients with comorbidities. Its effect on patients with pre-existing acute pancreatitis is not known. METHODS: We hereby, present 3 cases with severe acute pancreatitis with pe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IAP and EPC. Published by Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437538/ https://www.ncbi.nlm.nih.gov/pubmed/32859545 http://dx.doi.org/10.1016/j.pan.2020.08.008 |
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author | Elhence, Anshuman Mahapatra, Soumya Jagannath Vajpai, Tanmay Garg, Pramod Kumar |
author_facet | Elhence, Anshuman Mahapatra, Soumya Jagannath Vajpai, Tanmay Garg, Pramod Kumar |
author_sort | Elhence, Anshuman |
collection | PubMed |
description | BACKGROUND: Coronavirus disease 2019 (COVID-19) presents with myriad extra-pulmonary manifestation and a high mortality in patients with comorbidities. Its effect on patients with pre-existing acute pancreatitis is not known. METHODS: We hereby, present 3 cases with severe acute pancreatitis with persistent respiratory failure who acquired nosocomial COVID-19 during their hospital stay after recovery from respiratory failure. Their clinical course is highlighted which reflects on pathophysiology of organ dysfunction in these 2 disease states. RESULTS: None of the 3 patients with severe acute pancreatitis who developed nosocomial COVID-19 redeveloped respiratory failure due to COVID-19 despite having recently recovered from pancreatitis induced acute hypoxemic respiratory failure. Only one patient developed SARS-CoV2 induced moderate pneumonia. CONCLUSION: These cases highlight that host responses and mechanisms of lung injury might be different in severe acute pancreatitis and COVID-19. |
format | Online Article Text |
id | pubmed-7437538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | IAP and EPC. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74375382020-08-20 Acute pancreatitis and nosocomial COVID-19: Cause specific host responses may determine lung injury Elhence, Anshuman Mahapatra, Soumya Jagannath Vajpai, Tanmay Garg, Pramod Kumar Pancreatology Rapid Communication BACKGROUND: Coronavirus disease 2019 (COVID-19) presents with myriad extra-pulmonary manifestation and a high mortality in patients with comorbidities. Its effect on patients with pre-existing acute pancreatitis is not known. METHODS: We hereby, present 3 cases with severe acute pancreatitis with persistent respiratory failure who acquired nosocomial COVID-19 during their hospital stay after recovery from respiratory failure. Their clinical course is highlighted which reflects on pathophysiology of organ dysfunction in these 2 disease states. RESULTS: None of the 3 patients with severe acute pancreatitis who developed nosocomial COVID-19 redeveloped respiratory failure due to COVID-19 despite having recently recovered from pancreatitis induced acute hypoxemic respiratory failure. Only one patient developed SARS-CoV2 induced moderate pneumonia. CONCLUSION: These cases highlight that host responses and mechanisms of lung injury might be different in severe acute pancreatitis and COVID-19. IAP and EPC. Published by Elsevier B.V. 2020-10 2020-08-19 /pmc/articles/PMC7437538/ /pubmed/32859545 http://dx.doi.org/10.1016/j.pan.2020.08.008 Text en © 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Rapid Communication Elhence, Anshuman Mahapatra, Soumya Jagannath Vajpai, Tanmay Garg, Pramod Kumar Acute pancreatitis and nosocomial COVID-19: Cause specific host responses may determine lung injury |
title | Acute pancreatitis and nosocomial COVID-19: Cause specific host responses may determine lung injury |
title_full | Acute pancreatitis and nosocomial COVID-19: Cause specific host responses may determine lung injury |
title_fullStr | Acute pancreatitis and nosocomial COVID-19: Cause specific host responses may determine lung injury |
title_full_unstemmed | Acute pancreatitis and nosocomial COVID-19: Cause specific host responses may determine lung injury |
title_short | Acute pancreatitis and nosocomial COVID-19: Cause specific host responses may determine lung injury |
title_sort | acute pancreatitis and nosocomial covid-19: cause specific host responses may determine lung injury |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437538/ https://www.ncbi.nlm.nih.gov/pubmed/32859545 http://dx.doi.org/10.1016/j.pan.2020.08.008 |
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