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Insights into platinum-induced peripheral neuropathy–current perspective
Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437596/ https://www.ncbi.nlm.nih.gov/pubmed/32209761 http://dx.doi.org/10.4103/1673-5374.276321 |
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author | Lazić, Andrijana Popović, Jelena Paunesku, Tatjana Woloschak, Gayle E. Stevanović, Milena |
author_facet | Lazić, Andrijana Popović, Jelena Paunesku, Tatjana Woloschak, Gayle E. Stevanović, Milena |
author_sort | Lazić, Andrijana |
collection | PubMed |
description | Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the therapy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adducts correlates with neurotoxic severity and development of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complexity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment. |
format | Online Article Text |
id | pubmed-7437596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-74375962020-08-28 Insights into platinum-induced peripheral neuropathy–current perspective Lazić, Andrijana Popović, Jelena Paunesku, Tatjana Woloschak, Gayle E. Stevanović, Milena Neural Regen Res Review Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the therapy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adducts correlates with neurotoxic severity and development of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complexity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment. Wolters Kluwer - Medknow 2020-02-28 /pmc/articles/PMC7437596/ /pubmed/32209761 http://dx.doi.org/10.4103/1673-5374.276321 Text en Copyright: © 2020 Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Lazić, Andrijana Popović, Jelena Paunesku, Tatjana Woloschak, Gayle E. Stevanović, Milena Insights into platinum-induced peripheral neuropathy–current perspective |
title | Insights into platinum-induced peripheral neuropathy–current perspective |
title_full | Insights into platinum-induced peripheral neuropathy–current perspective |
title_fullStr | Insights into platinum-induced peripheral neuropathy–current perspective |
title_full_unstemmed | Insights into platinum-induced peripheral neuropathy–current perspective |
title_short | Insights into platinum-induced peripheral neuropathy–current perspective |
title_sort | insights into platinum-induced peripheral neuropathy–current perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437596/ https://www.ncbi.nlm.nih.gov/pubmed/32209761 http://dx.doi.org/10.4103/1673-5374.276321 |
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