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Diagnostic value of circulating tumor DNA in molecular characterization of glioma: A meta-analysis
INTRODUCTION: Circulating tumor DNA (ctDNA) has provided a minimally invasive approach for the detection of genetic mutations in glioma. However, the diagnostic value of ctDNA in glioma remains unclear. This meta-analysis was designed to investigate the diagnostic value of ctDNA, compared with the c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437834/ https://www.ncbi.nlm.nih.gov/pubmed/32871983 http://dx.doi.org/10.1097/MD.0000000000021196 |
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author | Kang, Yin Lin, Xiaohua Kang, Dezhi |
author_facet | Kang, Yin Lin, Xiaohua Kang, Dezhi |
author_sort | Kang, Yin |
collection | PubMed |
description | INTRODUCTION: Circulating tumor DNA (ctDNA) has provided a minimally invasive approach for the detection of genetic mutations in glioma. However, the diagnostic value of ctDNA in glioma remains unclear. This meta-analysis was designed to investigate the diagnostic value of ctDNA, compared with the current “criterion standard” tumor tissues. MATERIALS AND METHODS: The included studies were collected by searching PubMed, Web of Science, Cochrane Library, and Embase databases. All statistical analyses were performed using the STATA12.0 and Meta-DiSc1.4 software. RESULT: A total of 11 studies comprising 522 glioma patients met our inclusion criteria. The pooled sensitivity and specificity were 0.69 (95% confidence interval [CI] 0.66–0.73) and 0.98 (95% CI 0.96–0.99), respectively. The pooled diagnostic odds ratio was 23.27 (95% CI 13.69–39.53) and the area under the curve of the summary receiver operating characteristics curve was 0.90 (95% CI 0.89–0.92). CONCLUSIONS: ctDNA analysis is an effective method to detect the genetic mutation status in glioma patients with high specificity and relatively moderate sensitivity. The application of high-throughput technologies, the detection of patients with high-grade glioma, and sampling from cerebrospinal fluid could have higher diagnostic accuracy. The improvement of detection methods and more large-sample case–control studies are required in the future. |
format | Online Article Text |
id | pubmed-7437834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-74378342020-09-02 Diagnostic value of circulating tumor DNA in molecular characterization of glioma: A meta-analysis Kang, Yin Lin, Xiaohua Kang, Dezhi Medicine (Baltimore) 5700 INTRODUCTION: Circulating tumor DNA (ctDNA) has provided a minimally invasive approach for the detection of genetic mutations in glioma. However, the diagnostic value of ctDNA in glioma remains unclear. This meta-analysis was designed to investigate the diagnostic value of ctDNA, compared with the current “criterion standard” tumor tissues. MATERIALS AND METHODS: The included studies were collected by searching PubMed, Web of Science, Cochrane Library, and Embase databases. All statistical analyses were performed using the STATA12.0 and Meta-DiSc1.4 software. RESULT: A total of 11 studies comprising 522 glioma patients met our inclusion criteria. The pooled sensitivity and specificity were 0.69 (95% confidence interval [CI] 0.66–0.73) and 0.98 (95% CI 0.96–0.99), respectively. The pooled diagnostic odds ratio was 23.27 (95% CI 13.69–39.53) and the area under the curve of the summary receiver operating characteristics curve was 0.90 (95% CI 0.89–0.92). CONCLUSIONS: ctDNA analysis is an effective method to detect the genetic mutation status in glioma patients with high specificity and relatively moderate sensitivity. The application of high-throughput technologies, the detection of patients with high-grade glioma, and sampling from cerebrospinal fluid could have higher diagnostic accuracy. The improvement of detection methods and more large-sample case–control studies are required in the future. Lippincott Williams & Wilkins 2020-08-14 /pmc/articles/PMC7437834/ /pubmed/32871983 http://dx.doi.org/10.1097/MD.0000000000021196 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5700 Kang, Yin Lin, Xiaohua Kang, Dezhi Diagnostic value of circulating tumor DNA in molecular characterization of glioma: A meta-analysis |
title | Diagnostic value of circulating tumor DNA in molecular characterization of glioma: A meta-analysis |
title_full | Diagnostic value of circulating tumor DNA in molecular characterization of glioma: A meta-analysis |
title_fullStr | Diagnostic value of circulating tumor DNA in molecular characterization of glioma: A meta-analysis |
title_full_unstemmed | Diagnostic value of circulating tumor DNA in molecular characterization of glioma: A meta-analysis |
title_short | Diagnostic value of circulating tumor DNA in molecular characterization of glioma: A meta-analysis |
title_sort | diagnostic value of circulating tumor dna in molecular characterization of glioma: a meta-analysis |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437834/ https://www.ncbi.nlm.nih.gov/pubmed/32871983 http://dx.doi.org/10.1097/MD.0000000000021196 |
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