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Cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck: A PRISMA-compliant meta-analysis of randomized controlled trial

BACKGROUND: This meta-analysis was performed to incorporate newly published, high-quality randomized controlled trials (RCTs) to determine the effects of cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck. METHODS: The following electronic da...

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Autores principales: Liu, Binfeng, Li, Ang, Wang, Jialin, Wang, Hongbo, Zhai, Gongwei, Ma, Haohao, Lian, Xiaoyu, Zhang, Bo, Liu, Liyun, Gao, Yanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437858/
https://www.ncbi.nlm.nih.gov/pubmed/32872057
http://dx.doi.org/10.1097/MD.0000000000021731
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author Liu, Binfeng
Li, Ang
Wang, Jialin
Wang, Hongbo
Zhai, Gongwei
Ma, Haohao
Lian, Xiaoyu
Zhang, Bo
Liu, Liyun
Gao, Yanzheng
author_facet Liu, Binfeng
Li, Ang
Wang, Jialin
Wang, Hongbo
Zhai, Gongwei
Ma, Haohao
Lian, Xiaoyu
Zhang, Bo
Liu, Liyun
Gao, Yanzheng
author_sort Liu, Binfeng
collection PubMed
description BACKGROUND: This meta-analysis was performed to incorporate newly published, high-quality randomized controlled trials (RCTs) to determine the effects of cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck. METHODS: The following electronic databases were extensively searched from the inception of the database through December 2018: EMBASE, Medline, the Cochrane Library, and Web of Science. RCTs focusing on the outcomes of cemented and uncemented hemiarthroplasty were reviewed and screened for eligibility. We used the Cochrane Collaboration's Review Manager Software to perform meta-analyses. Two independent reviewers extracted the data and assessed the study quality and bias risk through the Cochrane Collaboration tool. Use fixed effect model or random effect model to pooled data. Cochran's Q statistic was used to evaluate heterogeneity, and I(2) statistic was used to quantify heterogeneity. RESULTS: Fifteen RCTs were enrolled (n = 3790) (uncemented hemiarthroplasty group = 1015; cemented hemiarthroplasty group = 1037) (mean age ranged from 70–85.3 years; all patients > 65 years). The meta-analysis showed that cemented hemiarthroplasty has a longer operating time (weighted mean difference, 8.03; 95% confidence interval (CI) 4.83–11.23; P < .00001), less pain (odds ratio, 0.48; 95% CI 4.83–11.23; P = .02), lower mortality 1-year (odds ratio, 0.78; 95% CI 0.62–0.98; P = .03) and fewer implant-related complications (odds ratio, 0.20; 95% CI 0.13–0.30; P < .00001) than Uncemented hemiarthroplasty. However, there are still some limitations in our study, such as the uniformity of the surgery administration programme and rehabilitation scheme, and the small sample size of the included studies. CONCLUSIONS: Cemented hemiarthroplasty for elderly patients with displaced fracture of femoral neck may acquire better functional results.
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spelling pubmed-74378582020-09-02 Cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck: A PRISMA-compliant meta-analysis of randomized controlled trial Liu, Binfeng Li, Ang Wang, Jialin Wang, Hongbo Zhai, Gongwei Ma, Haohao Lian, Xiaoyu Zhang, Bo Liu, Liyun Gao, Yanzheng Medicine (Baltimore) 7100 BACKGROUND: This meta-analysis was performed to incorporate newly published, high-quality randomized controlled trials (RCTs) to determine the effects of cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck. METHODS: The following electronic databases were extensively searched from the inception of the database through December 2018: EMBASE, Medline, the Cochrane Library, and Web of Science. RCTs focusing on the outcomes of cemented and uncemented hemiarthroplasty were reviewed and screened for eligibility. We used the Cochrane Collaboration's Review Manager Software to perform meta-analyses. Two independent reviewers extracted the data and assessed the study quality and bias risk through the Cochrane Collaboration tool. Use fixed effect model or random effect model to pooled data. Cochran's Q statistic was used to evaluate heterogeneity, and I(2) statistic was used to quantify heterogeneity. RESULTS: Fifteen RCTs were enrolled (n = 3790) (uncemented hemiarthroplasty group = 1015; cemented hemiarthroplasty group = 1037) (mean age ranged from 70–85.3 years; all patients > 65 years). The meta-analysis showed that cemented hemiarthroplasty has a longer operating time (weighted mean difference, 8.03; 95% confidence interval (CI) 4.83–11.23; P < .00001), less pain (odds ratio, 0.48; 95% CI 4.83–11.23; P = .02), lower mortality 1-year (odds ratio, 0.78; 95% CI 0.62–0.98; P = .03) and fewer implant-related complications (odds ratio, 0.20; 95% CI 0.13–0.30; P < .00001) than Uncemented hemiarthroplasty. However, there are still some limitations in our study, such as the uniformity of the surgery administration programme and rehabilitation scheme, and the small sample size of the included studies. CONCLUSIONS: Cemented hemiarthroplasty for elderly patients with displaced fracture of femoral neck may acquire better functional results. Lippincott Williams & Wilkins 2020-08-14 /pmc/articles/PMC7437858/ /pubmed/32872057 http://dx.doi.org/10.1097/MD.0000000000021731 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 7100
Liu, Binfeng
Li, Ang
Wang, Jialin
Wang, Hongbo
Zhai, Gongwei
Ma, Haohao
Lian, Xiaoyu
Zhang, Bo
Liu, Liyun
Gao, Yanzheng
Cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck: A PRISMA-compliant meta-analysis of randomized controlled trial
title Cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck: A PRISMA-compliant meta-analysis of randomized controlled trial
title_full Cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck: A PRISMA-compliant meta-analysis of randomized controlled trial
title_fullStr Cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck: A PRISMA-compliant meta-analysis of randomized controlled trial
title_full_unstemmed Cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck: A PRISMA-compliant meta-analysis of randomized controlled trial
title_short Cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck: A PRISMA-compliant meta-analysis of randomized controlled trial
title_sort cemented versus uncemented hemiarthroplasty for elderly patients with displaced fracture of the femoral neck: a prisma-compliant meta-analysis of randomized controlled trial
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437858/
https://www.ncbi.nlm.nih.gov/pubmed/32872057
http://dx.doi.org/10.1097/MD.0000000000021731
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