Brain microenvironment-driven resistance to immune and targeted therapies in acral melanoma

BACKGROUND: Combination treatments targeting the MEK-ERK pathway and checkpoint inhibitors have improved overall survival in melanoma. Resistance to treatment especially in the brain remains challenging, and rare disease subtypes such as acral melanoma are not typically included in trials. Here we p...

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Detalles Bibliográficos
Autores principales: Lee, Rebecca Jane, Khandelwal, Garima, Baenke, Franziska, Cannistraci, Alessio, Macleod, Kenneth, Mundra, Piyushkumar, Ashton, Garry, Mandal, Amit, Viros, Amaya, Gremel, Gabriela, Galvani, Elena, Smith, Matthew, Carragher, Neil, Dhomen, Nathalie, Miller, Crispin, Lorigan, Paul, Marais, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437885/
https://www.ncbi.nlm.nih.gov/pubmed/32817058
http://dx.doi.org/10.1136/esmoopen-2020-000707

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