Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes

Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-γ (IFN-γ), in offspring’s brains play a central role. IFN-γ activates an antiviral cellular state, limiting viral entry and replication. Moreover, IFN-γ is implicated in brain develo...

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Detalles Bibliográficos
Autores principales: Warre-Cornish, Katherine, Perfect, Leo, Nagy, Roland, Duarte, Rodrigo R. R., Reid, Matthew J., Raval, Pooja, Mueller, Annett, Evans, Amanda L., Couch, Amalie, Ghevaert, Cédric, McAlonan, Grainne, Loth, Eva, Murphy, Declan, Powell, Timothy R., Vernon, Anthony C., Srivastava, Deepak P., Price, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438100/
https://www.ncbi.nlm.nih.gov/pubmed/32875100
http://dx.doi.org/10.1126/sciadv.aay9506

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