Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability

Maintaining biocatalyst stability and activity is a critical challenge. Chondroitinase ABC (ChABC) has shown promise in central nervous system (CNS) regeneration, yet its therapeutic utility is severely limited by instability. We computationally reengineered ChABC by introducing 37, 55, and 92 amino...

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Detalles Bibliográficos
Autores principales: Hettiaratchi, Marian H., O’Meara, Matthew J., O’Meara, Teresa R., Pickering, Andrew J., Letko-Khait, Nitzan, Shoichet, Molly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438101/
https://www.ncbi.nlm.nih.gov/pubmed/32875119
http://dx.doi.org/10.1126/sciadv.abc6378

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