The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling

Akt is a critical protein kinase that governs cancer cell growth and metabolism. Akt appears to be autoinhibited by an intramolecular interaction between its N-terminal pleckstrin homology (PH) domain and kinase domain, which is relieved by C-tail phosphorylation, but the precise molecular mechanism...

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Detalles Bibliográficos
Autores principales: Chu, Nam, Viennet, Thibault, Bae, Hwan, Salguero, Antonieta, Boeszoermenyi, Andras, Arthanari, Haribabu, Cole, Philip A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438110/
https://www.ncbi.nlm.nih.gov/pubmed/32744507
http://dx.doi.org/10.7554/eLife.59151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438110/
https://www.ncbi.nlm.nih.gov/pubmed/32744507
http://dx.doi.org/10.7554/eLife.59151

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