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The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
Akt is a critical protein kinase that governs cancer cell growth and metabolism. Akt appears to be autoinhibited by an intramolecular interaction between its N-terminal pleckstrin homology (PH) domain and kinase domain, which is relieved by C-tail phosphorylation, but the precise molecular mechanism...
Autores principales: | Chu, Nam, Viennet, Thibault, Bae, Hwan, Salguero, Antonieta, Boeszoermenyi, Andras, Arthanari, Haribabu, Cole, Philip A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438110/ https://www.ncbi.nlm.nih.gov/pubmed/32744507 http://dx.doi.org/10.7554/eLife.59151 |
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