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Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020—a cross-sectional study

OBJECTIVE: In Berlin, the first public severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing site started 1 day after the first case in the city occurred. We describe epidemiological and clinical characteristics and aim at identifying risk factors for SARS-CoV-2 detection during the f...

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Autores principales: Maechler, Friederike, Gertler, Maximilian, Hermes, Julia, van Loon, Welmoed, Schwab, Frank, Piening, Brar, Rojansky, Shay, Hommes, Franziska, Kausch, Franka, Lindner, Andreas K., Burock, Susen, Rössig, Heike, Hartmann, Claudia, Kirchberger, Valerie, Thieme, Alexander, Behnke, Michael, Gastmeier, Petra, Mockenhaupt, Frank P., Seybold, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438270/
https://www.ncbi.nlm.nih.gov/pubmed/32827715
http://dx.doi.org/10.1016/j.cmi.2020.08.017
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author Maechler, Friederike
Gertler, Maximilian
Hermes, Julia
van Loon, Welmoed
Schwab, Frank
Piening, Brar
Rojansky, Shay
Hommes, Franziska
Kausch, Franka
Lindner, Andreas K.
Burock, Susen
Rössig, Heike
Hartmann, Claudia
Kirchberger, Valerie
Thieme, Alexander
Behnke, Michael
Gastmeier, Petra
Mockenhaupt, Frank P.
Seybold, Joachim
author_facet Maechler, Friederike
Gertler, Maximilian
Hermes, Julia
van Loon, Welmoed
Schwab, Frank
Piening, Brar
Rojansky, Shay
Hommes, Franziska
Kausch, Franka
Lindner, Andreas K.
Burock, Susen
Rössig, Heike
Hartmann, Claudia
Kirchberger, Valerie
Thieme, Alexander
Behnke, Michael
Gastmeier, Petra
Mockenhaupt, Frank P.
Seybold, Joachim
author_sort Maechler, Friederike
collection PubMed
description OBJECTIVE: In Berlin, the first public severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing site started 1 day after the first case in the city occurred. We describe epidemiological and clinical characteristics and aim at identifying risk factors for SARS-CoV-2 detection during the first 6 weeks of operation. METHODS: Testing followed national recommendations, but was also based on the physician's discretion. We related patient characteristics to SARS-CoV-2 test positivity for exploratory analyses using a cross-sectional, observational study design. RESULTS: Between 3 March and 13 April 2020, 5179 individuals attended the site (median age 34 years; interquartile range 26–47 years). The median time since disease onset was 4 days (interquartile range 2–7 days). Among 4333 persons tested, 333 (7.7%) were positive. Test positivity increased up to 10.3% (96/929) during the first 3 weeks and then declined, paralleling Germany's lock-down and the course of the epidemic in Berlin. Strict adherence to testing guidelines resulted in 10.4% (262/2530) test positivity, compared with 3.9% (71/1803) among individuals tested for other indications. A nightclub was a transmission hotspot; 27.7% (26/94) of one night's visitors were found positive. Smell and/or taste dysfunction indicated coronavirus disease 2019 (COVID-19) with 85.6% specificity (95% CI 82.1%–88.1%). Four per cent (14/333) of those infected were asymptomatic. Risk factors for detection of SARS-CoV-2 infection were recent contact with a positive case (second week after contact, OR 3.42; 95% CI 2.48–4.71), travel to regions of high pandemic activity (e.g. Austria, OR 4.16; 95% CI 2.48–6.99), recent onset of symptoms (second week, OR 3.61; 95% CI 1.87–6.98) and an impaired sense of smell/taste (4.08; 95% CI 2.36–7.03). CONCLUSIONS: In this young population, early-onset presentation of COVID-19 resembled flu-like symptoms, except for smell and/or taste dysfunction. Risk factors for SARS-CoV-2 detection were return from regions with high incidence and contact with confirmed SARS-CoV-2 cases, particularly when tests were administered within the first 2 weeks after contact and/or onset of symptoms.
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spelling pubmed-74382702020-08-20 Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020—a cross-sectional study Maechler, Friederike Gertler, Maximilian Hermes, Julia van Loon, Welmoed Schwab, Frank Piening, Brar Rojansky, Shay Hommes, Franziska Kausch, Franka Lindner, Andreas K. Burock, Susen Rössig, Heike Hartmann, Claudia Kirchberger, Valerie Thieme, Alexander Behnke, Michael Gastmeier, Petra Mockenhaupt, Frank P. Seybold, Joachim Clin Microbiol Infect Original Article OBJECTIVE: In Berlin, the first public severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing site started 1 day after the first case in the city occurred. We describe epidemiological and clinical characteristics and aim at identifying risk factors for SARS-CoV-2 detection during the first 6 weeks of operation. METHODS: Testing followed national recommendations, but was also based on the physician's discretion. We related patient characteristics to SARS-CoV-2 test positivity for exploratory analyses using a cross-sectional, observational study design. RESULTS: Between 3 March and 13 April 2020, 5179 individuals attended the site (median age 34 years; interquartile range 26–47 years). The median time since disease onset was 4 days (interquartile range 2–7 days). Among 4333 persons tested, 333 (7.7%) were positive. Test positivity increased up to 10.3% (96/929) during the first 3 weeks and then declined, paralleling Germany's lock-down and the course of the epidemic in Berlin. Strict adherence to testing guidelines resulted in 10.4% (262/2530) test positivity, compared with 3.9% (71/1803) among individuals tested for other indications. A nightclub was a transmission hotspot; 27.7% (26/94) of one night's visitors were found positive. Smell and/or taste dysfunction indicated coronavirus disease 2019 (COVID-19) with 85.6% specificity (95% CI 82.1%–88.1%). Four per cent (14/333) of those infected were asymptomatic. Risk factors for detection of SARS-CoV-2 infection were recent contact with a positive case (second week after contact, OR 3.42; 95% CI 2.48–4.71), travel to regions of high pandemic activity (e.g. Austria, OR 4.16; 95% CI 2.48–6.99), recent onset of symptoms (second week, OR 3.61; 95% CI 1.87–6.98) and an impaired sense of smell/taste (4.08; 95% CI 2.36–7.03). CONCLUSIONS: In this young population, early-onset presentation of COVID-19 resembled flu-like symptoms, except for smell and/or taste dysfunction. Risk factors for SARS-CoV-2 detection were return from regions with high incidence and contact with confirmed SARS-CoV-2 cases, particularly when tests were administered within the first 2 weeks after contact and/or onset of symptoms. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. 2020-12 2020-08-20 /pmc/articles/PMC7438270/ /pubmed/32827715 http://dx.doi.org/10.1016/j.cmi.2020.08.017 Text en © 2020 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Maechler, Friederike
Gertler, Maximilian
Hermes, Julia
van Loon, Welmoed
Schwab, Frank
Piening, Brar
Rojansky, Shay
Hommes, Franziska
Kausch, Franka
Lindner, Andreas K.
Burock, Susen
Rössig, Heike
Hartmann, Claudia
Kirchberger, Valerie
Thieme, Alexander
Behnke, Michael
Gastmeier, Petra
Mockenhaupt, Frank P.
Seybold, Joachim
Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020—a cross-sectional study
title Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020—a cross-sectional study
title_full Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020—a cross-sectional study
title_fullStr Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020—a cross-sectional study
title_full_unstemmed Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020—a cross-sectional study
title_short Epidemiological and clinical characteristics of SARS-CoV-2 infections at a testing site in Berlin, Germany, March and April 2020—a cross-sectional study
title_sort epidemiological and clinical characteristics of sars-cov-2 infections at a testing site in berlin, germany, march and april 2020—a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438270/
https://www.ncbi.nlm.nih.gov/pubmed/32827715
http://dx.doi.org/10.1016/j.cmi.2020.08.017
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