Tumor-Reprogrammed Stromal BCAT1 Fuels Branched Chain Ketoacid Dependency in Stromal-Rich PDAC Tumors

Branched chain amino acids (BCAAs) supply both carbon and nitrogen in pancreatic cancers, and their increased levels have been associated with increased risk of pancreatic ductal adenocarcinomas (PDACs). It remains unclear, however, how stromal cells regulate BCAA metabolism in PDAC cells and how mu...

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Detalles Bibliográficos
Autores principales: Zhu, Ziwen, Achreja, Abhinav, Meurs, Noah, Animasahun, Olamide, Owen, Sarah, Mittal, Anjali, Parikh, Pooja, Lo, Ting-Wen, Franco-Barraza, Janusz, Shi, Jiaqi, Gunchick, Valerie, Sherman, Mara H., Cukierman, Edna, Pickering, Andrew M., Maitra, Anirban, Sahai, Vaibhav, Morgan, Meredith A., Nagrath, Sunitha, Lawrence, Theodore S., Nagrath, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438275/
https://www.ncbi.nlm.nih.gov/pubmed/32694827
http://dx.doi.org/10.1038/s42255-020-0226-5

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