(99m)Tc-labeled nanocolloid drugs: development methods

The work considers the problem of obtaining nanocolloid radiopharmaceuticals (RPs) and studying their functional suitability for diagnosing sentinel lymph nodes (SLN) in cancer patients. Two principal approaches to the formation of technetium-99m-labeled particles based on inorganic and organic matr...

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Detalles Bibliográficos
Autores principales: Sadkin, Vladimir, Sкuridin, Viktor, Nesterov, Evgeny, Stasyuk, Elena, Rogov, Alexander, Varlamova, Natalya, Zelchan, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438322/
https://www.ncbi.nlm.nih.gov/pubmed/32814811
http://dx.doi.org/10.1038/s41598-020-70991-2
Descripción
Sumario:The work considers the problem of obtaining nanocolloid radiopharmaceuticals (RPs) and studying their functional suitability for diagnosing sentinel lymph nodes (SLN) in cancer patients. Two principal approaches to the formation of technetium-99m-labeled particles based on inorganic and organic matrices were considered when carrying out research to develop methods for the production of nanocolloid RPs. The composition of the reagents and the conditions for obtaining nanocolloid radiopharmaceuticals were determined. The functional suitability of new RPs for scintigraphic diagnostics of sentinel lymph nodes has been studied.

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