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Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction
Recent studies on cull cows have shown that ovarian abnormalities, particularly ovarian insufficiency, are the main cause of reproductive failure. The aim of this study was to treat bovine ovarian failure with intraovarian administration of autologous platelet rich plasma (PRP), which is rich in gro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438405/ https://www.ncbi.nlm.nih.gov/pubmed/32903508 http://dx.doi.org/10.3389/fvets.2020.00517 |
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author | Cremonesi, Fausto Bonfanti, Stefano Idda, Antonella Lange-Consiglio, Anna |
author_facet | Cremonesi, Fausto Bonfanti, Stefano Idda, Antonella Lange-Consiglio, Anna |
author_sort | Cremonesi, Fausto |
collection | PubMed |
description | Recent studies on cull cows have shown that ovarian abnormalities, particularly ovarian insufficiency, are the main cause of reproductive failure. The aim of this study was to treat bovine ovarian failure with intraovarian administration of autologous platelet rich plasma (PRP), which is rich in growth factors, chemokines, and cytokines that could stimulate follicular growth and steroidogenesis. Twelve cows with ovarian hypofunction were enrolled in the study and they were randomly allocated in control group (CTR) and treated group (six animal for group). In the treated group, only five animals received the PRP treatment because intraovarian administration was hindered in one by a rectovaginal fistula. Animals of control group were treated by intraovarian administration of physiological solution. In the 4 weeks after PRP injection, a mild to strong increase in progesterone (PRG) concentrations was detected in four of the five cows treated. Artificial insemination (AI) resulted in four pregnancies that are still ongoing (7th month). Intraovarian administration of PRP improved ovarian function after 2 months of treatment. This effect may be due to reduction of follicular atresia or to revitalization of dormant oocytes allowing restoration of fertility. |
format | Online Article Text |
id | pubmed-7438405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74384052020-09-03 Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction Cremonesi, Fausto Bonfanti, Stefano Idda, Antonella Lange-Consiglio, Anna Front Vet Sci Veterinary Science Recent studies on cull cows have shown that ovarian abnormalities, particularly ovarian insufficiency, are the main cause of reproductive failure. The aim of this study was to treat bovine ovarian failure with intraovarian administration of autologous platelet rich plasma (PRP), which is rich in growth factors, chemokines, and cytokines that could stimulate follicular growth and steroidogenesis. Twelve cows with ovarian hypofunction were enrolled in the study and they were randomly allocated in control group (CTR) and treated group (six animal for group). In the treated group, only five animals received the PRP treatment because intraovarian administration was hindered in one by a rectovaginal fistula. Animals of control group were treated by intraovarian administration of physiological solution. In the 4 weeks after PRP injection, a mild to strong increase in progesterone (PRG) concentrations was detected in four of the five cows treated. Artificial insemination (AI) resulted in four pregnancies that are still ongoing (7th month). Intraovarian administration of PRP improved ovarian function after 2 months of treatment. This effect may be due to reduction of follicular atresia or to revitalization of dormant oocytes allowing restoration of fertility. Frontiers Media S.A. 2020-08-13 /pmc/articles/PMC7438405/ /pubmed/32903508 http://dx.doi.org/10.3389/fvets.2020.00517 Text en Copyright © 2020 Cremonesi, Bonfanti, Idda and Lange-Consiglio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Cremonesi, Fausto Bonfanti, Stefano Idda, Antonella Lange-Consiglio, Anna Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction |
title | Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction |
title_full | Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction |
title_fullStr | Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction |
title_full_unstemmed | Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction |
title_short | Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction |
title_sort | platelet rich plasma for regenerative medicine treatment of bovine ovarian hypofunction |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438405/ https://www.ncbi.nlm.nih.gov/pubmed/32903508 http://dx.doi.org/10.3389/fvets.2020.00517 |
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