The Rad53(CHK1/CHK2)-Spt21(NPAT) and Tel1(ATM) axes couple glucose tolerance to histone dosage and subtelomeric silencing

The DNA damage response (DDR) coordinates DNA metabolism with nuclear and non-nuclear processes. The DDR kinase Rad53(CHK1/CHK2) controls histone degradation to assist DNA repair. However, Rad53 deficiency causes histone-dependent growth defects in the absence of DNA damage, pointing out unknown phy...

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Detalles Bibliográficos
Autores principales: Bruhn, Christopher, Ajazi, Arta, Ferrari, Elisa, Lanz, Michael Charles, Batrin, Renaud, Choudhary, Ramveer, Walvekar, Adhish, Laxman, Sunil, Longhese, Maria Pia, Fabre, Emmanuelle, Smolka, Marcus Bustamente, Foiani, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438486/
https://www.ncbi.nlm.nih.gov/pubmed/32814778
http://dx.doi.org/10.1038/s41467-020-17961-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438486/
https://www.ncbi.nlm.nih.gov/pubmed/32814778
http://dx.doi.org/10.1038/s41467-020-17961-4

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