Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition

Amine compounds biosynthesis using ω-transaminases has received considerable attention in the pharmaceutical industry. However, the application of ω-transaminases was hampered by the fundamental challenge of severe by-product inhibition. Here, we report that ω-transaminase CrmG from Actinoalloteichu...

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Detalles Bibliográficos
Autores principales: Xu, Jinxin, Tang, Xiaowen, Zhu, Yiguang, Yu, Zhijun, Su, Kai, Zhang, Yulong, Dong, Yan, Zhu, Weiming, Zhang, Changsheng, Wu, Ruibo, Liu, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438487/
https://www.ncbi.nlm.nih.gov/pubmed/32814814
http://dx.doi.org/10.1038/s42003-020-01184-w

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