Cargando…

WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m(6)A-dependent manner

N(6)-methyladenosine (m(6)A) regulators are involved in the progression of various cancers via regulating m(6)A modification. However, the potential role and mechanism of the m(6)A modification in osteosarcoma remains obscure. In this study, WTAP was found to be highly expressed in osteosarcoma tiss...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Shijie, Li, Yuezhan, Zhi, Shuang, Ding, Zhiyu, Wang, Weiguo, Peng, Yi, Huang, Yan, Zheng, Ruping, Yu, Haiyang, Wang, Jianlong, Hu, Minghua, Miao, Jinglei, Li, Jinsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438489/ https://www.ncbi.nlm.nih.gov/pubmed/32814762 http://dx.doi.org/10.1038/s41419-020-02847-6

Ejemplares similares

Tanshinone I inhibits the growth and metastasis of osteosarcoma via suppressing JAK/STAT3 signalling pathway
por: Wang, Weiguo, et al.
Publicado: (2019)

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis
por: Chen, Shijie, et al.
Publicado: (2020)

RNA adenosine modifications related to prognosis and immune infiltration in osteosarcoma
por: Chen, Shijie, et al.
Publicado: (2022)

An Innovative Prone Position Using a Body-Shape Plaster Bed and Skull Traction for Posterior Cervical Spine Fracture Surgeries
por: Ding, Zhiyu, et al.
Publicado: (2022)

HMBOX1, a member of the homeobox family: current research progress
por: Jiang, Yu, et al.
Publicado: (2023)

Multifunctional inorganic biomaterials: New weapons targeting osteosarcoma
por: Wang, Dong, et al.
Publicado: (2023)

HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells
por: Ma, HanLin, et al.
Publicado: (2015)

HIF-1α Regulated WTAP Overexpression Promoting the Warburg Effect of Ovarian Cancer by m6A-Dependent Manner
por: Lyu, Yuanyuan, et al.
Publicado: (2022)

Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential
por: Fan, Yongfei, et al.
Publicado: (2022)

Loss of WTAP Impairs Early Parthenogenetic Embryo Development
por: Hao, Jindong, et al.
Publicado: (2021)

METTL3 regulates WTAP protein homeostasis
por: Sorci, Melissa, et al.
Publicado: (2018)

Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)
por: Li, Xinzhi, et al.
Publicado: (2022)

CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-α in Postmenopausal Osteoporosis
por: Liu, Zhuochao, et al.
Publicado: (2020)

Metabolomic analysis reveals the influence of HMBOX1 on RAW264.7 cells proliferation based on UPLC-MS/MS
por: Jiang, Wen, et al.
Publicado: (2023)

PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6
por: Jia, Yachun, et al.
Publicado: (2023)

Exosome-Derived From Sepsis Patients' Blood Promoted Pyroptosis of Cardiomyocytes by Regulating miR-885-5p/HMBOX1
por: Tu, Guo-wei, et al.
Publicado: (2022)

Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children
por: Tang, Jue, et al.
Publicado: (2021)

The Emerging, Multifaceted Role of WTAP in Cancer and Cancer Therapeutics
por: Ju, Guomin, et al.
Publicado: (2023)

N(6)-adenosine-methyltransferase-14 promotes glioma tumorigenesis by repressing argininosuccinate synthase 1 expression in an m6A-dependent manner
por: Miao, You-Qing, et al.
Publicado: (2022)

Relationship between the genetic expression of WTAP and bladder cancer and patient prognosis
por: Chen, Lezhong, et al.
Publicado: (2018)

Upregulated WTAP expression in colorectal cancer correlates with tumor site and differentiation
por: Dong, Xiao-Fang, et al.
Publicado: (2022)

N(6)-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m(6)A/FOXM1 axis
por: Ren, Zhipeng, et al.
Publicado: (2022)

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
por: Ping, Xiao-Li, et al.
Publicado: (2014)

WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche
por: Jia, Gong-Xue, et al.
Publicado: (2020)

MicroRNA-1305 Inhibits the Stemness of LCSCs and Tumorigenesis by Repressing the UBE2T-Dependent Akt-Signaling Pathway
por: Wei, Xiaoyong, et al.
Publicado: (2019)

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

WTAP regulates autophagy in colon cancer cells by inhibiting FLNA through N6-methyladenosine
por: Huang, Liang, et al.
Publicado: (2023)

HMBOX1 attenuates LPS-induced periodontal ligament stem cell injury by inhibiting CXCL10 expression through the NF-κB signaling pathway
por: Nie, Minyuan, et al.
Publicado: (2022)

SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B
por: Yu, Zhibin, et al.
Publicado: (2017)

WTAP Gene Variants Confer Hepatoblastoma Susceptibility: A Seven-Center Case-Control Study
por: Zhuo, Zhen-Jian, et al.
Publicado: (2020)

Knockdown of DDX46 Inhibits the Invasion and Tumorigenesis in Osteosarcoma Cells
por: Jiang, Feng, et al.
Publicado: (2017)

High expression of WTAP leads to poor prognosis of gastric cancer by influencing tumour‐associated T lymphocyte infiltration
por: Li, Huafu, et al.
Publicado: (2020)

5,2′‐dibromo‐2,4′,5′‐trihydroxydiphenylmethanone attenuates LPS‐induced inflammation and ROS production in EA.hy926 cells via HMBOX1 induction
por: Yuan, Hong‐Xia, et al.
Publicado: (2018)

MicroRNA‐501‐3p inhibits the proliferation of kidney cancer cells by targeting WTAP
por: He, Liujia, et al.
Publicado: (2021)

Identification of WTAP-related genes by weighted gene co-expression network analysis in ovarian cancer
por: Wang, Jing, et al.
Publicado: (2020)

Deciphering the Signaling Mechanisms of Osteosarcoma Tumorigenesis
por: Nirala, Bikesh K., et al.
Publicado: (2023)

Comprehensive analysis about prognostic and immunological role of WTAP in pan-cancer
por: Lei, Jiangchu, et al.
Publicado: (2022)

Potential impact of WTAP and YTHDF2 on tumor immunity in lung adenocarcinoma
por: Zhang, Xinyu, et al.
Publicado: (2022)

WTAP gene variants and susceptibility to ovarian endometriosis in a Chinese population
por: Wan, Zixian, et al.
Publicado: (2023)

WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation
por: Song, Kai, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pcfmb29ah9tb9ho0hr2ugifvgo