Chemotherapeutic resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2-antioxidant pathway activation

Overexpression of epithelial cell adhesion molecule (EpCAM) has been associated with chemotherapeutic resistance, leads to aggressive tumor behavior, and results in an adverse clinical outcome. The molecular mechanism by which EpCAM enrichment is linked to therapeutic resistance via Nrf2, a key regu...

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Detalles Bibliográficos
Autores principales: Noman, Abu Shadat M., Parag, Rashed R., Rashid, Muhammad I., Islam, Shafiqul, Rahman, Mohammad Z., Chowdhury, Ali A., Sultana, Afrin, Jerin, Chandsultana, Siddiqua, Ayesha, Rahman, Lutfur, Nayeem, Junayed, Akther, Sonam, Baidya, Sunanda, Shil, Rajib K., Rahman, Mizanur, Shirin, Afsana, Mahmud, Reaz, Hossain, S. M. Ikram, Sumi, Sharmin A., Chowdhury, Arfina, Basher, Shabnam B., Hasan, Abul, Bithy, Shammy, Aklima, Jannatul, Chowdhury, Nabila, Hasan, Muhammad N., Banu, Tahmina, Chowdhury, Srikanta, Hossain, Muhammad M., Yeger, Herman, Farhat, Walid A., Islam, Syed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438524/
https://www.ncbi.nlm.nih.gov/pubmed/32814771
http://dx.doi.org/10.1038/s41419-020-02907-x

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