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Nearest-neighbor amino acids of specificity-determining residues influence the activity of engineered Cre-type recombinases

The tyrosine-type site-specific DNA recombinase Cre recombines its target site, loxP, with high activity and specificity without cross-recombining the target sites of highly related recombinases. Understanding how Cre achieves this precision is key to be able to rationally engineer site-specific rec...

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Detalles Bibliográficos
Autores principales:	Soni, Anjali, Augsburg, Martina, Buchholz, Frank, Pisabarro, M. Teresa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438526/ https://www.ncbi.nlm.nih.gov/pubmed/32814809 http://dx.doi.org/10.1038/s41598-020-70867-5

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