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NAD(+) Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death

In addition to its central role in mediating oxidation reduction in fuel metabolism and bioenergetics, nicotinamide adenine dinucleotide (NAD(+)) has emerged as a vital co-substrate for a number of proteins involved in diverse cellular processes, including sirtuins, poly(ADP-ribose) polymerases and...

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Autores principales: Xu, Weiyi, Li, Le, Zhang, Lilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438569/
https://www.ncbi.nlm.nih.gov/pubmed/32903597
http://dx.doi.org/10.3389/fphys.2020.00901
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author Xu, Weiyi
Li, Le
Zhang, Lilei
author_facet Xu, Weiyi
Li, Le
Zhang, Lilei
author_sort Xu, Weiyi
collection PubMed
description In addition to its central role in mediating oxidation reduction in fuel metabolism and bioenergetics, nicotinamide adenine dinucleotide (NAD(+)) has emerged as a vital co-substrate for a number of proteins involved in diverse cellular processes, including sirtuins, poly(ADP-ribose) polymerases and cyclic ADP-ribose synthetases. The connection with aging and age-associated diseases has led to a new wave of research in the cardiovascular field. Here, we review the basics of NAD(+) homeostasis, the molecular physiology and new advances in ischemic-reperfusion injury, heart failure, and arrhythmias, all of which are associated with increased risks for sudden cardiac death. Finally, we summarize the progress of NAD(+)-boosting therapy in human cardiovascular diseases and the challenges for future studies.
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spelling pubmed-74385692020-09-03 NAD(+) Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death Xu, Weiyi Li, Le Zhang, Lilei Front Physiol Physiology In addition to its central role in mediating oxidation reduction in fuel metabolism and bioenergetics, nicotinamide adenine dinucleotide (NAD(+)) has emerged as a vital co-substrate for a number of proteins involved in diverse cellular processes, including sirtuins, poly(ADP-ribose) polymerases and cyclic ADP-ribose synthetases. The connection with aging and age-associated diseases has led to a new wave of research in the cardiovascular field. Here, we review the basics of NAD(+) homeostasis, the molecular physiology and new advances in ischemic-reperfusion injury, heart failure, and arrhythmias, all of which are associated with increased risks for sudden cardiac death. Finally, we summarize the progress of NAD(+)-boosting therapy in human cardiovascular diseases and the challenges for future studies. Frontiers Media S.A. 2020-08-13 /pmc/articles/PMC7438569/ /pubmed/32903597 http://dx.doi.org/10.3389/fphys.2020.00901 Text en Copyright © 2020 Xu, Li and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Xu, Weiyi
Li, Le
Zhang, Lilei
NAD(+) Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death
title NAD(+) Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death
title_full NAD(+) Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death
title_fullStr NAD(+) Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death
title_full_unstemmed NAD(+) Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death
title_short NAD(+) Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death
title_sort nad(+) metabolism as an emerging therapeutic target for cardiovascular diseases associated with sudden cardiac death
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438569/
https://www.ncbi.nlm.nih.gov/pubmed/32903597
http://dx.doi.org/10.3389/fphys.2020.00901
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