Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease

Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Zuo, Zhenying, Jing, Kaipeng, Wu, Hongluan, Wang, Shujun, Ye, Lin, Li, Zhihang, Yang, Chen, Pan, Qingjun, Liu, Wei Jing, Liu, Hua-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438724/
https://www.ncbi.nlm.nih.gov/pubmed/32903665
http://dx.doi.org/10.3389/fphys.2020.00935
Descripción
Sumario:Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pathological contexts. We also briefly review and discuss the crosstalk between mitophagy and renal disease, highlighting its modulation as a potentially effective therapeutic strategy to treat kidney diseases such as acute kidney injury (AKI), diabetic kidney disease (DKD), and lupus nephritis (LN).

Ejemplares similares