Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease

Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Zuo, Zhenying, Jing, Kaipeng, Wu, Hongluan, Wang, Shujun, Ye, Lin, Li, Zhihang, Yang, Chen, Pan, Qingjun, Liu, Wei Jing, Liu, Hua-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438724/
https://www.ncbi.nlm.nih.gov/pubmed/32903665
http://dx.doi.org/10.3389/fphys.2020.00935
_version_ 1783572845275643904
author Zuo, Zhenying
Jing, Kaipeng
Wu, Hongluan
Wang, Shujun
Ye, Lin
Li, Zhihang
Yang, Chen
Pan, Qingjun
Liu, Wei Jing
Liu, Hua-feng
author_facet Zuo, Zhenying
Jing, Kaipeng
Wu, Hongluan
Wang, Shujun
Ye, Lin
Li, Zhihang
Yang, Chen
Pan, Qingjun
Liu, Wei Jing
Liu, Hua-feng
author_sort Zuo, Zhenying
collection PubMed
description Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pathological contexts. We also briefly review and discuss the crosstalk between mitophagy and renal disease, highlighting its modulation as a potentially effective therapeutic strategy to treat kidney diseases such as acute kidney injury (AKI), diabetic kidney disease (DKD), and lupus nephritis (LN).
format Online
Article
Text
id pubmed-7438724
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-74387242020-09-03 Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease Zuo, Zhenying Jing, Kaipeng Wu, Hongluan Wang, Shujun Ye, Lin Li, Zhihang Yang, Chen Pan, Qingjun Liu, Wei Jing Liu, Hua-feng Front Physiol Physiology Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pathological contexts. We also briefly review and discuss the crosstalk between mitophagy and renal disease, highlighting its modulation as a potentially effective therapeutic strategy to treat kidney diseases such as acute kidney injury (AKI), diabetic kidney disease (DKD), and lupus nephritis (LN). Frontiers Media S.A. 2020-08-07 /pmc/articles/PMC7438724/ /pubmed/32903665 http://dx.doi.org/10.3389/fphys.2020.00935 Text en Copyright © 2020 Zuo, Jing, Wu, Wang, Ye, Li, Yang, Pan, Liu and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zuo, Zhenying
Jing, Kaipeng
Wu, Hongluan
Wang, Shujun
Ye, Lin
Li, Zhihang
Yang, Chen
Pan, Qingjun
Liu, Wei Jing
Liu, Hua-feng
Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease
title Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease
title_full Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease
title_fullStr Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease
title_full_unstemmed Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease
title_short Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease
title_sort mechanisms and functions of mitophagy and potential roles in renal disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438724/
https://www.ncbi.nlm.nih.gov/pubmed/32903665
http://dx.doi.org/10.3389/fphys.2020.00935
work_keys_str_mv AT zuozhenying mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease
AT jingkaipeng mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease
AT wuhongluan mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease
AT wangshujun mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease
AT yelin mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease
AT lizhihang mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease
AT yangchen mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease
AT panqingjun mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease
AT liuweijing mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease
AT liuhuafeng mechanismsandfunctionsofmitophagyandpotentialrolesinrenaldisease

Ejemplares similares