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Application of Physiologically‐Based Pharmacokinetic Modeling to Predict Gastric pH‐Dependent Drug–Drug Interactions for Weak Base Drugs

Weak‐base drugs are susceptible to drug–drug interactions (DDIs) when coadministered with gastric acid–reducing agents (ARAs). We developed PBPK models to evaluate the potential of such pH‐dependent DDIs for four weak‐base drugs, i.e., tapentadol, darunavir, erlotinib, and saxagliptin. The physiolog...

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Detalles Bibliográficos
Autores principales:	Dong, Zhongqi, Li, Jia, Wu, Fang, Zhao, Ping, Lee, Sue‐Chih, Zhang, Lillian, Seo, Paul, Zhang, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438815/ https://www.ncbi.nlm.nih.gov/pubmed/32633893 http://dx.doi.org/10.1002/psp4.12541

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